@article{001294b57f81476196db3116085dc469,
title = "Genetic diversity of the African malaria vector Anopheles gambiae",
abstract = "The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.",
author = "{The Anopheles gambiae 1000 Genomes Consortium} and Alistair Miles and Harding, {Nicholas J.} and Giordano Bott{\`a} and Clarkson, {Chris S.} and Tiago Ant{\~a}o and Krzysztof Kozak and Schrider, {Daniel R.} and Kern, {Andrew D.} and Seth Redmond and Igor Sharakhov and Pearson, {Richard D.} and Christina Bergey and Fontaine, {Michael C.} and Donnelly, {Martin J.} and Lawniczak, {Mara K.N.} and Diego Ayala and Besansky, {Nora J.} and Austin Burt and Beniamino Caputo and Torre, {Alessandra Della} and Godfray, {H. Charles J.} and Hahn, {Matthew W.} and Janet Midega and Neafsey, {Daniel E.} and Samantha O'Loughlin and Jo{\~a}o Pinto and Riehle, {Michelle M.} and Vernick, {Kenneth D.} and David Weetman and Wilding, {Craig S.} and White, {Bradley J.} and Troco, {Arlete D.} and Abdoulaye Diabat{\'e} and Carlo Costantini and Rohatgi, {Kyanne R.} and Nohal Elissa and Boubacar Coulibaly and Jo{\~a}o Dinis and Charles Mbogo and Philip Bejon and Mawejje, {Henry D.} and Jim Stalker and Kirk Rockett and Eleanor Drury and Daniel Mead and Anna Jeffreys and Christina Hubbart and Kate Rowlands and Isaacs, {Alison T.} and Dushyanth Jyothi",
year = "2017",
month = dec,
day = "7",
doi = "10.1038/nature24995",
language = "English",
volume = "552",
pages = "96--100",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
}
