Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula

S. Cortes; C. Chicharro; I. Cruz; J. M. Cristovão; C. Cañavate; L. Campino

doi:10.1111/j.1863-2378.2010.01374.x

Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula

S. Cortes, C. Chicharro, I. Cruz, J. M. Cristovão, C. Cañavate, L. Campino

Instituto de Higiene e Medicina Tropical (IHMT)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Zoonoses And Public Health
Volume	58
Issue number	4
DOIs	https://doi.org/10.1111/j.1863-2378.2010.01374.x
Publication status	Published - Jun 2011

Keywords

Genetic diversity
Leishmania infantum
Portugal
Spain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1863-2378.2010.01374.x

Cite this

@article{a595b497afc643e282580205870e4828,

title = "Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula",

abstract = "Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.",

keywords = "Genetic diversity, Leishmania infantum, Portugal, Spain",

author = "S. Cortes and C. Chicharro and I. Cruz and Cristov{\~a}o, {J. M.} and C. Ca{\~n}avate and L. Campino",

year = "2011",

month = jun,

doi = "10.1111/j.1863-2378.2010.01374.x",

language = "English",

volume = "58",

pages = "234--237",

journal = "Zoonoses And Public Health",

issn = "1863-1959",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula

AU - Cortes, S.

AU - Chicharro, C.

AU - Cruz, I.

AU - Cristovão, J. M.

AU - Cañavate, C.

AU - Campino, L.

PY - 2011/6

Y1 - 2011/6

N2 - Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.

AB - Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.

KW - Genetic diversity

KW - Leishmania infantum

KW - Portugal

KW - Spain

UR - http://www.scopus.com/inward/record.url?scp=79955863962&partnerID=8YFLogxK

U2 - 10.1111/j.1863-2378.2010.01374.x

DO - 10.1111/j.1863-2378.2010.01374.x

M3 - Article

C2 - 21040506

AN - SCOPUS:79955863962

SN - 1863-1959

VL - 58

SP - 234

EP - 237

JO - Zoonoses And Public Health

JF - Zoonoses And Public Health

IS - 4

ER -

Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this