Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula

S. Cortes, C. Chicharro, I. Cruz, J. M. Cristovão, C. Cañavate, L. Campino

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalZoonoses And Public Health
Volume58
Issue number4
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Genetic diversity
  • Leishmania infantum
  • Portugal
  • Spain

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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