Espondilite Anquilosante e sua base genética.

Translated title of the contribution: Genetic basis of ankylosing spondylitis

F. Pimentel dos Santos, E. Bastos, D. Ligeiro, A. F. Mourão, R. Chaves, H. Trindade, H. Guedes-Pinto, Jaime Branco

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Ankylosing spondylitis (AS) is a common rheumatic condition, highly heritable. Much of the genetic contribution to the disease lies in the major histocompatibility complex (MHC). The association with the allele group HLA-B*27 has been described worldwide for 30 years. On the other hand, genome wide scans have provided some interesting results showing that other MHC and non-MHC genes could be implicated either in disease susceptibility and phenotypic manifestations. Different hypothesis for disease pathophysiology have been investigated which contribute for a better understanding of the genetic basis of AS. This review aims to summarize the status of the knowledge in this exciting area. New data may, in a near future, change the screening of patients and generate new insights for the emergence of novel therapies.

Translated title of the contributionGenetic basis of ankylosing spondylitis
Original languagePortuguese
Pages (from-to)243-252
Number of pages10
JournalActa reumatológica portuguesa
Volume32
Issue number3
Publication statusPublished - Jul 2007

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