Genetic and statistical study of HIV integration in the human genome

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Abstract

Integration of the human immunodeficiency virus (HIV) DNA into human genome is essential for HIV-induced disease. The human genome is organized into chromosomes and within these we can define the chromosomal fragile sites. Our aim is to contribute to help clarifying the integration sites preferences of HIV1 and HIV2 in fragile or non-fragile regions. Here we apply statistical techniques, namely non-parametric tests and analysis of variance for analyzing two sets of data of HIV1 and HIV2 integrations in the human genome. The results show that the integrations occur significantly with more intensity in the non-fragile regions of the human genome and that the HIV1 in particular has the major contribution to this fact. This study could have implications in human disease.

Original languageEnglish
Title of host publication11th International Conference of Numerical Analysis and Applied Mathematics 2013, ICNAAM 2013
EditorsT. Simos, G. Psihoyios, C. Tsitouras
PublisherAmerican Institute of Physics Inc.
Pages813-816
Number of pages4
ISBN (Print)9780735411845
DOIs
Publication statusPublished - 19 Nov 2013
Event11th International Conference of Numerical Analysis and Applied Mathematics 2013, ICNAAM 2013 - Rhodes, Greece
Duration: 21 Sep 201327 Sep 2013

Publication series

NameAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
Volume1558
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference11th International Conference of Numerical Analysis and Applied Mathematics 2013, ICNAAM 2013
CountryGreece
CityRhodes
Period21/09/1327/09/13

Keywords

  • ANOVA
  • HIV
  • Human Genome
  • non-parametric tests

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  • Cite this

    Sequeira, I. J., Gonçalves, J., Moreira, E., Mexia, J. T., Rueff, J., & Brás, A. (2013). Genetic and statistical study of HIV integration in the human genome. In T. Simos, G. Psihoyios, & C. Tsitouras (Eds.), 11th International Conference of Numerical Analysis and Applied Mathematics 2013, ICNAAM 2013 (pp. 813-816). (AIP Conference Proceedings; Vol. 1558). American Institute of Physics Inc.. https://doi.org/10.1063/1.4825619