Generation and biological evaluation of the products formed from the exposure of Phenothiazine to a 266 nm laser beam

T. Alexandru, M. L. Pascu, B. Danko, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, A. Armada, M. Viveiros, L. Amaral

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Phenothiazine exposed to white light or UV radiation undergoes a variety of reactions that result in the degradation of the parental compound and the formation of new species. Chlorpromazine exposed to the 266 nm laser beam of given energy levels yielded species derived from it, whose number increased with the exposure duration. At distinct time intervals the irradiation products were evaluated by spectrophotometry between 200-1500 nm, Thin Layer Chromatography, and for antimicrobial activity of Chlorpromazine against different test organisms such as Staphylococcus aureus.

Original languageEnglish
Title of host publicationProc. SPIE 8882, ROMOPTO 2012 - Tenth Conference on Optics: Micro- to Nanophotonics III
Number of pages8
Volume88820T
DOIs
Publication statusPublished - 10 Jun 2013
Event10th Conference on Optics: Micro- to Nanophotonics III, ROMOPTO 2012 - Bucharest
Duration: 3 Sep 20136 Sep 2013

Conference

Conference10th Conference on Optics: Micro- to Nanophotonics III, ROMOPTO 2012
CityBucharest
Period3/09/136/09/13

Keywords

  • absorption spectroscopy
  • Chlorpromazine
  • CPZ
  • photo-degradation.
  • Promazine
  • PZ
  • TLC

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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