Abstract
The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).
This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.
Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; P
Among Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.
| Original language | English |
|---|---|
| Article number | e5652 |
| Number of pages | 6 |
| Journal | Hiv Medicine |
| Volume | 95 |
| Issue number | 51 |
| DOIs | |
| Publication status | Published - Dec 2016 |
Keywords
- ankylosing spondylitis
- gender differences
- psoriatic spondylitis
- spondyloarthritis
- QUALITY-OF-LIFE
- DIAGNOSTIC-CRITERIA
- WORK DISABILITY
- ARTHRITIS
- WOMEN
- INDEX
- ONSET
- MEN
- PREVALENCE
- AGE
Cite this
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Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort. / Landi, Margarita; Maldonado-Ficco, Hernan; Perez-Alamino, Rodolfo; Maldonado-Cocco, Jose A.; Citera, Gustavo; Arturi, Pablo; Sampaio-Barros, Percival D.; Alvarado, Diana E. Flores; Burgos-Vargas, Ruben; Santos, Elena; Palleiro, Daniel; Gutierrez, Miguel A.; Vieyra-Sousa, Elsa; Pimentel-Santos, Fernando; Paira, Sergio O.; Berman, Alberto; Barrezueta, Claudia Vera; Vazquez-Mellado, Janitzia; Collantes-Estevez, Eduardo; RESPONDIA Grp; Fdn Reumatologica Argentina Dr Osv.
In: Hiv Medicine, Vol. 95, No. 51, e5652, 12.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort
AU - Landi, Margarita
AU - Maldonado-Ficco, Hernan
AU - Perez-Alamino, Rodolfo
AU - Maldonado-Cocco, Jose A.
AU - Citera, Gustavo
AU - Arturi, Pablo
AU - Sampaio-Barros, Percival D.
AU - Alvarado, Diana E. Flores
AU - Burgos-Vargas, Ruben
AU - Santos, Elena
AU - Palleiro, Daniel
AU - Gutierrez, Miguel A.
AU - Vieyra-Sousa, Elsa
AU - Pimentel-Santos, Fernando
AU - Paira, Sergio O.
AU - Berman, Alberto
AU - Barrezueta, Claudia Vera
AU - Vazquez-Mellado, Janitzia
AU - Collantes-Estevez, Eduardo
AU - RESPONDIA Grp
AU - Fdn Reumatologica Argentina Dr Osv
PY - 2016/12
Y1 - 2016/12
N2 - The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; PAmong Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.
AB - The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; PAmong Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.
KW - ankylosing spondylitis
KW - gender differences
KW - psoriatic spondylitis
KW - spondyloarthritis
KW - QUALITY-OF-LIFE
KW - DIAGNOSTIC-CRITERIA
KW - WORK DISABILITY
KW - ARTHRITIS
KW - WOMEN
KW - INDEX
KW - ONSET
KW - MEN
KW - PREVALENCE
KW - AGE
U2 - 10.1097/MD.0000000000005652
DO - 10.1097/MD.0000000000005652
M3 - Article
VL - 95
JO - Hiv Medicine
JF - Hiv Medicine
SN - 1464-2662
IS - 51
M1 - e5652
ER -