Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort

Margarita Landi, Hernan Maldonado-Ficco, Rodolfo Perez-Alamino, Jose A. Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D. Sampaio-Barros, Diana E. Flores Alvarado, Ruben Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A. Gutierrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O. Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez, RESPONDIA Grp & 1 others Fdn Reumatologica Argentina Dr Osv

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).

This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.

Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; P

Among Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.

Original languageEnglish
Article numbere5652
Number of pages6
JournalHiv Medicine
Volume95
Issue number51
DOIs
Publication statusPublished - Dec 2016

Keywords

  • ankylosing spondylitis
  • gender differences
  • psoriatic spondylitis
  • spondyloarthritis
  • QUALITY-OF-LIFE
  • DIAGNOSTIC-CRITERIA
  • WORK DISABILITY
  • ARTHRITIS
  • WOMEN
  • INDEX
  • ONSET
  • MEN
  • PREVALENCE
  • AGE

Cite this

Landi, M., Maldonado-Ficco, H., Perez-Alamino, R., Maldonado-Cocco, J. A., Citera, G., Arturi, P., ... Fdn Reumatologica Argentina Dr Osv (2016). Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort. Hiv Medicine, 95(51), [e5652]. https://doi.org/10.1097/MD.0000000000005652
Landi, Margarita ; Maldonado-Ficco, Hernan ; Perez-Alamino, Rodolfo ; Maldonado-Cocco, Jose A. ; Citera, Gustavo ; Arturi, Pablo ; Sampaio-Barros, Percival D. ; Alvarado, Diana E. Flores ; Burgos-Vargas, Ruben ; Santos, Elena ; Palleiro, Daniel ; Gutierrez, Miguel A. ; Vieyra-Sousa, Elsa ; Pimentel-Santos, Fernando ; Paira, Sergio O. ; Berman, Alberto ; Barrezueta, Claudia Vera ; Vazquez-Mellado, Janitzia ; Collantes-Estevez, Eduardo ; RESPONDIA Grp ; Fdn Reumatologica Argentina Dr Osv. / Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort. In: Hiv Medicine. 2016 ; Vol. 95, No. 51.
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title = "Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort",
abstract = "The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2{\%}). Among patients with psoriatic spondylitis, male predominance was lower (57.8{\%}), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2{\%} vs 6.9{\%}; PAmong Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.",
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author = "Margarita Landi and Hernan Maldonado-Ficco and Rodolfo Perez-Alamino and Maldonado-Cocco, {Jose A.} and Gustavo Citera and Pablo Arturi and Sampaio-Barros, {Percival D.} and Alvarado, {Diana E. Flores} and Ruben Burgos-Vargas and Elena Santos and Daniel Palleiro and Gutierrez, {Miguel A.} and Elsa Vieyra-Sousa and Fernando Pimentel-Santos and Paira, {Sergio O.} and Alberto Berman and Barrezueta, {Claudia Vera} and Janitzia Vazquez-Mellado and Eduardo Collantes-Estevez and {RESPONDIA Grp} and {Fdn Reumatologica Argentina Dr Osv}",
year = "2016",
month = "12",
doi = "10.1097/MD.0000000000005652",
language = "English",
volume = "95",
journal = "Hiv Medicine",
issn = "1464-2662",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "51",

}

Landi, M, Maldonado-Ficco, H, Perez-Alamino, R, Maldonado-Cocco, JA, Citera, G, Arturi, P, Sampaio-Barros, PD, Alvarado, DEF, Burgos-Vargas, R, Santos, E, Palleiro, D, Gutierrez, MA, Vieyra-Sousa, E, Pimentel-Santos, F, Paira, SO, Berman, A, Barrezueta, CV, Vazquez-Mellado, J, Collantes-Estevez, E, RESPONDIA Grp & Fdn Reumatologica Argentina Dr Osv 2016, 'Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort', Hiv Medicine, vol. 95, no. 51, e5652. https://doi.org/10.1097/MD.0000000000005652

Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort. / Landi, Margarita; Maldonado-Ficco, Hernan; Perez-Alamino, Rodolfo; Maldonado-Cocco, Jose A.; Citera, Gustavo; Arturi, Pablo; Sampaio-Barros, Percival D.; Alvarado, Diana E. Flores; Burgos-Vargas, Ruben; Santos, Elena; Palleiro, Daniel; Gutierrez, Miguel A.; Vieyra-Sousa, Elsa; Pimentel-Santos, Fernando; Paira, Sergio O.; Berman, Alberto; Barrezueta, Claudia Vera; Vazquez-Mellado, Janitzia; Collantes-Estevez, Eduardo; RESPONDIA Grp; Fdn Reumatologica Argentina Dr Osv.

In: Hiv Medicine, Vol. 95, No. 51, e5652, 12.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort

AU - Landi, Margarita

AU - Maldonado-Ficco, Hernan

AU - Perez-Alamino, Rodolfo

AU - Maldonado-Cocco, Jose A.

AU - Citera, Gustavo

AU - Arturi, Pablo

AU - Sampaio-Barros, Percival D.

AU - Alvarado, Diana E. Flores

AU - Burgos-Vargas, Ruben

AU - Santos, Elena

AU - Palleiro, Daniel

AU - Gutierrez, Miguel A.

AU - Vieyra-Sousa, Elsa

AU - Pimentel-Santos, Fernando

AU - Paira, Sergio O.

AU - Berman, Alberto

AU - Barrezueta, Claudia Vera

AU - Vazquez-Mellado, Janitzia

AU - Collantes-Estevez, Eduardo

AU - RESPONDIA Grp

AU - Fdn Reumatologica Argentina Dr Osv

PY - 2016/12

Y1 - 2016/12

N2 - The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; PAmong Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.

AB - The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; PAmong Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.

KW - ankylosing spondylitis

KW - gender differences

KW - psoriatic spondylitis

KW - spondyloarthritis

KW - QUALITY-OF-LIFE

KW - DIAGNOSTIC-CRITERIA

KW - WORK DISABILITY

KW - ARTHRITIS

KW - WOMEN

KW - INDEX

KW - ONSET

KW - MEN

KW - PREVALENCE

KW - AGE

U2 - 10.1097/MD.0000000000005652

DO - 10.1097/MD.0000000000005652

M3 - Article

VL - 95

JO - Hiv Medicine

JF - Hiv Medicine

SN - 1464-2662

IS - 51

M1 - e5652

ER -