TY - GEN
T1 - Gas Chromatography-Ion Mobility Spectrometry Instrument for Medical Applications
T2 - 12th IFIP WG 5.5/SOCOLNET Advanced Doctoral Conference on Computing, Electrical and Industrial Systems, DoCEIS 2021
AU - Fernandes, Jorge M.
AU - Vassilenko, Valentina
AU - Moura, Pedro C.
AU - Fetter, Viktor
N1 - info:eu-repo/grantAgreement/FCT/OE/PD%2FBDE%2F130204%2F2017/PT#
info:eu-repo/grantAgreement/FCT/OE/PD%2FBDE%2F150627%2F2020/PT#
PY - 2021
Y1 - 2021
N2 - Medical diagnosis research is driven into the development of non-invasive diagnosis devices centered in fast and precise analytical tools and instrumentation. This led to Volatile Organic Compounds (VOCs) being identified as metabolomics biomarkers for several diseases, including respiratory infections, cancer and even COVID 19 non-invasive test. While VOCs give a direct access to physiological states, their applicability requires detections at low concentration ranges (ppbv-pptv). However, its clinical success is strongly dependent on precise and robust calibration methods. In this work we describe a calibration protocol of volatile organic compounds in low concentration range (ppbv-pptv) for analytical GC-IMS technology which offer a quick in-situ results in medical diagnosis. The calibration is based on permeation tubes which are monitored using thermogravimetric methods to estimate mass loss ratio over time establishing emitted concentrations. Notwithstanding future improvements, herein calibration methodology results are a promising step forward in medical diagnosis and applications.
AB - Medical diagnosis research is driven into the development of non-invasive diagnosis devices centered in fast and precise analytical tools and instrumentation. This led to Volatile Organic Compounds (VOCs) being identified as metabolomics biomarkers for several diseases, including respiratory infections, cancer and even COVID 19 non-invasive test. While VOCs give a direct access to physiological states, their applicability requires detections at low concentration ranges (ppbv-pptv). However, its clinical success is strongly dependent on precise and robust calibration methods. In this work we describe a calibration protocol of volatile organic compounds in low concentration range (ppbv-pptv) for analytical GC-IMS technology which offer a quick in-situ results in medical diagnosis. The calibration is based on permeation tubes which are monitored using thermogravimetric methods to estimate mass loss ratio over time establishing emitted concentrations. Notwithstanding future improvements, herein calibration methodology results are a promising step forward in medical diagnosis and applications.
KW - Analytical techniques
KW - Artificial intelligence
KW - Automated systems
KW - Calibration
KW - Medical diagnosis
KW - Metabolomics
KW - Volatile organic compounds
UR - http://www.scopus.com/inward/record.url?scp=85111957974&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-78288-7_34
DO - 10.1007/978-3-030-78288-7_34
M3 - Conference contribution
AN - SCOPUS:85111957974
SN - 9783030782870
T3 - IFIP Advances in Information and Communication Technology
SP - 349
EP - 357
BT - Technological Innovation for Applied AI Systems - 12th IFIP WG 5.5/SOCOLNET Advanced Doctoral Conference on Computing, Electrical and Industrial Systems, DoCEIS 2021, Proceedings
A2 - Camarinha-Matos, Luis M.
A2 - Ferreira, Pedro
A2 - Brito, Guilherme
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 7 July 2021 through 9 July 2021
ER -
