@article{6535aab736a54d3fa65a7857865c8e7e,
title = "Formate Dehydrogenases Reduce CO2 Rather than HCO3−: An Electrochemical Demonstration",
abstract = "Mo/W formate dehydrogenases catalyze the reversible reduction of CO2 species to formate. It is thought that the substrate is CO2 and not a hydrated species like HCO3−, but there is still no indisputable evidence for this, in spite of the extreme importance of the nature of the substrate for mechanistic studies. We devised a simple electrochemical method to definitively demonstrate that the substrate of formate dehydrogenases is indeed CO2.",
keywords = "bioelectrochemistry, carbonic anhydrase, CO dehydrogenase, CO reduction, protein film voltammetry",
author = "Marta Meneghello and Oliveira, \{Ana Rita\} and Aurore Jacq-Bailly and Pereira, \{In{\^e}s A.C.\} and Christophe L{\'e}ger and Vincent Fourmond",
note = "Funding Information: The authors acknowledge support from CNRS, Agence Nationale de la Recherche (grants ANR-14-CE05-0010, ANR-15-CE05-0020, ANR-17-CE11-002), and Region PACA. The project leading to this publication has received funding from Excellence Initiative of Aix-Marseille University?A*Midex, a French ?Investissements d'Avenir? program. M.M., A.B., C.L., and V.F. are members of the French Bioinorganic Chemistry group (http://frenchbic.cnrs.fr). The authors also thank Funda??o para a Ci?ncia e Tecnologia (Portugal) for fellowship SFRH/BD/ 116515/2016, grant PTDC/BII-BBF/2050/2020, and R\&D unit MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020). European Union's Horizon 2020 research and innovation program (Grant agreement no. 810856) is also acknowledged. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = apr,
day = "26",
doi = "10.1002/anie.202101167",
language = "English",
volume = "60",
pages = "9964--9967",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley \& Sons, Ltd.",
number = "18",
}