Formate Dehydrogenases Reduce CO2 Rather than HCO3: An Electrochemical Demonstration

Marta Meneghello, Ana Rita Oliveira, Aurore Jacq-Bailly, Inês A.C. Pereira, Christophe Léger, Vincent Fourmond

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Mo/W formate dehydrogenases catalyze the reversible reduction of CO2 species to formate. It is thought that the substrate is CO2 and not a hydrated species like HCO3, but there is still no indisputable evidence for this, in spite of the extreme importance of the nature of the substrate for mechanistic studies. We devised a simple electrochemical method to definitively demonstrate that the substrate of formate dehydrogenases is indeed CO2.

Original languageEnglish
Pages (from-to)9964-9967
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number18
Publication statusPublished - 26 Apr 2021


  • bioelectrochemistry
  • carbonic anhydrase
  • CO dehydrogenase
  • CO reduction
  • protein film voltammetry


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