Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences

Aida Esteves, João Piedade, Cândida Santos, Teresa Venenno, Wanda F. Canas-Ferreira, Ricardo Parreira

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for the three collected samples (1992, 1995, and 1997) for both individuals. A discontinuous replacement of sequences suggests activation of latent viruses present in reservoirs, a process that has been documented for the HIV-1 infection but unreported so far for HIV-2. The nucleotide sequences presented in this work have been assigned accession numbers AJ400276 to AJ400319.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume17
Issue number3
DOIs
Publication statusPublished - 10 Feb 2001

Keywords

  • Unclassified drug
  • Virus protein
  • Envelope protein
  • Glycoprotein gp 105

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