First iron-catalyzed guanylation of amines: a simple and highly efficient protocol to guanidines

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Abstract

The first iron-catalyzed guanylation of amines is reported. Commercially available Fe(OAc)(2) acts as an excellent catalyst for the addition of amines to carbodiimides. The reaction is broadly applicable to a variety of primary, secondary, and heterocyclic amines, and tolerates a wide range of functionalities allowing the easy preparation of a large family of guanidines. The low price and low toxicity of the commercially available iron catalyst make this methodology highly attractive.
Original languageUnknown
Pages (from-to)5156-5158
JournalTetrahedron Letters
Volume53
Issue number38
DOIs
Publication statusPublished - 1 Jan 2012

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