First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

Original languageEnglish
Article number96
JournalAntibiotics
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

Colistin
Acinetobacter baumannii
Portugal
Klebsiella pneumoniae
Virulence
Screening
Carbapenems
Tertiary Care Centers
Clone Cells
Genes
Polymerase Chain Reaction
tigecycline
carbapenemase

Keywords

  • A. Baumannii
  • Antimicrobial resistance
  • Colistin
  • Gram-negative bacteria
  • K. Pneumoniae
  • KPC-3 carbapenemase
  • Tigecycline

Cite this

Caneiras, Cátia ; Calisto, Filipa ; da Silva, Gabriela Jorge ; Lito, Luis ; Melo-Cristino, José ; Duarte, Aida. / First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal. In: Antibiotics. 2018 ; Vol. 7, No. 4.
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abstract = "Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.",
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First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal. / Caneiras, Cátia; Calisto, Filipa; da Silva, Gabriela Jorge; Lito, Luis; Melo-Cristino, José; Duarte, Aida.

In: Antibiotics, Vol. 7, No. 4, 96, 01.12.2018.

Research output: Contribution to journalArticle

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T1 - First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

AU - Caneiras, Cátia

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AU - Melo-Cristino, José

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