Abstract
Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
Original language | English |
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Article number | 96 |
Journal | Antibiotics |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Dec 2018 |
Keywords
- A. Baumannii
- Antimicrobial resistance
- Colistin
- Gram-negative bacteria
- K. Pneumoniae
- KPC-3 carbapenemase
- Tigecycline