Factors implicated in the generation and persistence of long-lived plasma cell-mediated autoimmunity

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12 Citations (Scopus)

Abstract

Autoimmune diseases are frequently associated with the production of autoantibodies by cells that escaped the protective mechanisms that control self-tolerance. Some of these cells develop into long-lived plasma cells which are predominantly located in the bone marrow. The generation of this particular type of cell requires specific migration, differentiation, and survival signals. The identification of some of the factors involved in these pathways has permitted the development of specific therapeutic approaches and may even provide investigators with further new therapeutic targets, particularly in autoimmune diseases associated with persistent autoantibody production. We reviewed the existing evidence for the mechanisms implicated in the perpetuation of long-lived plasma cells and the most recent therapeutic proposals in this context. (C) 2011 Elsevier B.V. All rights reserved.
Original languageUnknown
Pages (from-to)375-382
JournalAutoimmunity Reviews
Volume10
Issue number7
DOIs
Publication statusPublished - 1 Jan 2011

Cite this

@article{202f79c752184d778003e38264e6f731,
title = "Factors implicated in the generation and persistence of long-lived plasma cell-mediated autoimmunity",
abstract = "Autoimmune diseases are frequently associated with the production of autoantibodies by cells that escaped the protective mechanisms that control self-tolerance. Some of these cells develop into long-lived plasma cells which are predominantly located in the bone marrow. The generation of this particular type of cell requires specific migration, differentiation, and survival signals. The identification of some of the factors involved in these pathways has permitted the development of specific therapeutic approaches and may even provide investigators with further new therapeutic targets, particularly in autoimmune diseases associated with persistent autoantibody production. We reviewed the existing evidence for the mechanisms implicated in the perpetuation of long-lived plasma cells and the most recent therapeutic proposals in this context. (C) 2011 Elsevier B.V. All rights reserved.",
keywords = "bone-marrow, memory, niches, systemic-lupus-erythematosus, disease-activity, bxsb-yaa, sjogrens-syndrome, Therapeutic, b-cells, Long-lived, Survival, targets, mice, lymphocyte, baff, cells, activating, stimulator, plasma, serum, factor, levels, rheumatoid-arthritis",
author = "Alves, {Jos{\'e} Ant{\'o}nio Pereira Delgado}",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.autrev.2010.12.007",
language = "Unknown",
volume = "10",
pages = "375--382",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier Science B.V., Amsterdam.",
number = "7",

}

TY - JOUR

T1 - Factors implicated in the generation and persistence of long-lived plasma cell-mediated autoimmunity

AU - Alves, José António Pereira Delgado

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Autoimmune diseases are frequently associated with the production of autoantibodies by cells that escaped the protective mechanisms that control self-tolerance. Some of these cells develop into long-lived plasma cells which are predominantly located in the bone marrow. The generation of this particular type of cell requires specific migration, differentiation, and survival signals. The identification of some of the factors involved in these pathways has permitted the development of specific therapeutic approaches and may even provide investigators with further new therapeutic targets, particularly in autoimmune diseases associated with persistent autoantibody production. We reviewed the existing evidence for the mechanisms implicated in the perpetuation of long-lived plasma cells and the most recent therapeutic proposals in this context. (C) 2011 Elsevier B.V. All rights reserved.

AB - Autoimmune diseases are frequently associated with the production of autoantibodies by cells that escaped the protective mechanisms that control self-tolerance. Some of these cells develop into long-lived plasma cells which are predominantly located in the bone marrow. The generation of this particular type of cell requires specific migration, differentiation, and survival signals. The identification of some of the factors involved in these pathways has permitted the development of specific therapeutic approaches and may even provide investigators with further new therapeutic targets, particularly in autoimmune diseases associated with persistent autoantibody production. We reviewed the existing evidence for the mechanisms implicated in the perpetuation of long-lived plasma cells and the most recent therapeutic proposals in this context. (C) 2011 Elsevier B.V. All rights reserved.

KW - bone-marrow

KW - memory

KW - niches

KW - systemic-lupus-erythematosus

KW - disease-activity

KW - bxsb-yaa

KW - sjogrens-syndrome

KW - Therapeutic

KW - b-cells

KW - Long-lived

KW - Survival

KW - targets

KW - mice

KW - lymphocyte

KW - baff

KW - cells

KW - activating

KW - stimulator

KW - plasma

KW - serum

KW - factor

KW - levels

KW - rheumatoid-arthritis

U2 - 10.1016/j.autrev.2010.12.007

DO - 10.1016/j.autrev.2010.12.007

M3 - Article

VL - 10

SP - 375

EP - 382

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 7

ER -