Facile conversion of O-silyl protected sugars into their corresponding formates using POCl 3·DMF complex

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23 Citations (Scopus)

Abstract

The direct O-formylation of two selectively protected sugar derivatives using the Vilsmeier-Haack (V-H) complex POCl 3·DMF was studied. Primary O-TBDMS and O-TBDPS ethers of sucrose, the most common disaccharide, underwent regio and chemoselective O-formylation with this formylating agent. This conversion was also studied with a monosaccharide analogue.

Original languageEnglish
Pages (from-to)9235-9243
Number of pages9
JournalTetrahedron
Volume60
Issue number41
DOIs
Publication statusPublished - 4 Oct 2004

Keywords

  • Carbohydrates
  • Regio and chemoselective O-formylation
  • Vilsmeier-Haack (V-H) complex

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