TY - JOUR
T1 - FAAH rs324420 Polymorphism
T2 - Biological Pathways, Impact on Elite Athletic Performance and Insights for Sport Medicine
AU - Silva, Hugo Henrique
AU - Tavares, Valéria
AU - Neto, Beatriz Vieira
AU - Cerqueira, Fátima
AU - Medeiros, Rui
AU - Silva, Maria Raquel G.
N1 - Funding Information:
This research was supported by research funds from Portuguese League Against Cancer—Northern Branch (grant reference: LPCC-NRN2023-BVN) and Fundação para a Ciência e Tecnologia (FCT), co-financed by European Social Funds (FSE) and national funds of MCTES (grant reference: 2020.08969.BD).
Funding Information:
We would like to thank the Instituto Português de Oncologia do Porto (IPOP) and the Fundação para a Ciência e Tecnologia (FCT). V.T. is a PhD scholarship holder (Grant reference: 2020.08969.BD) supported by Fundação para a Ciência e Tecnologia (FCT), co-financed by European Social Funds (FSE) and national funds of MCTES. B.V.N. is a research fellow (grant reference: LPCC-NRN2023-BVN) supported by the Portuguese League Against Cancer (NRNorte). The funder institutions had no role in the manuscript writing and the decision to publish it.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/10
Y1 - 2023/10
N2 - Gene variation linked to physiological functions is recognised to affect elite athletic performance by modulating training and competition-enabling behaviour. The fatty acid amide hydrolase (FAAH) has been investigated as a good candidate for drug targeting, and recently, its single-nucleotide polymorphism (SNP) rs324420 was reported to be associated with athletic performance. Given the implications, the biological pathways of this genetic polymorphism linked to elite athletic performance, considering sport type, psychological traits and sports injuries, need to be dissected. Thus, a narrative review of the literature concerning the biological mechanisms of this SNP was undertaken. In addition to its role in athletic performance, FAAH rs324420 is also involved in important mechanisms underlying human psychopathologies, including substance abuse and neural dysfunctions. However, cumulative evidence concerning the C385A variant is inconsistent. Therefore, validation studies considering homogeneous sports modalities are required to better define the role of this SNP in elite athletic performance and its impact on stress coping, pain regulation and inflammation control.
AB - Gene variation linked to physiological functions is recognised to affect elite athletic performance by modulating training and competition-enabling behaviour. The fatty acid amide hydrolase (FAAH) has been investigated as a good candidate for drug targeting, and recently, its single-nucleotide polymorphism (SNP) rs324420 was reported to be associated with athletic performance. Given the implications, the biological pathways of this genetic polymorphism linked to elite athletic performance, considering sport type, psychological traits and sports injuries, need to be dissected. Thus, a narrative review of the literature concerning the biological mechanisms of this SNP was undertaken. In addition to its role in athletic performance, FAAH rs324420 is also involved in important mechanisms underlying human psychopathologies, including substance abuse and neural dysfunctions. However, cumulative evidence concerning the C385A variant is inconsistent. Therefore, validation studies considering homogeneous sports modalities are required to better define the role of this SNP in elite athletic performance and its impact on stress coping, pain regulation and inflammation control.
KW - elite athlete
KW - FAAH
KW - gene
KW - performance
KW - polymorphism
KW - sport
KW - success
UR - http://www.scopus.com/inward/record.url?scp=85175272808&partnerID=8YFLogxK
U2 - 10.3390/genes14101946
DO - 10.3390/genes14101946
M3 - Review article
C2 - 37895295
AN - SCOPUS:85175272808
SN - 0920-8569
VL - 14
JO - Genes
JF - Genes
IS - 10
M1 - 1946
ER -
