TY - JOUR
T1 - Extraction of antibiotics using aqueous two-phase systems based on ethyl lactate and thiosulphate salts
AU - Zakrzewska, Małgorzata E.
AU - Nunes, Ana V. M.
AU - Barot, Aarti R.
AU - Fernández-Castané, Alfred
AU - Visak, Zoran P.
AU - Kiatkittipong, Worapon
AU - Najdanovic-Visak, Vesna
N1 - Funding Information:
This work was supported by Aston University internal grant and the Fundação para a Ciência e Tecnologia (FCT), project UIDB/00100/2020 of Centro de Química Estrutural, PTDC/EQU-EPQ/31926/2017, UIDB/50006/2020 of the Associate Laboratory for Green Chemistry – LAQV, UIDB/00100/2020 of the Centro de Química Estrutural – CQE, and IF/01374/2014.
Publisher Copyright:
© 2021
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Ethyl lactate is a hydrophilic solvent produced from bio-renewable sources (bioethanol and lactic acid produced from corn fermentation) that is considered as a “green” solvent due to its extremely low toxicity, biodegradability and negligible eco-toxicity. This work focuses on the utilization of ethyl lactate to form aqueous two-phase systems (ATPS) in the presence of inorganic salts for the extraction of antibiotics from aqueous solutions. The performance of three thiosulfate salts (Na2S2O3, K2S2O3 and (NH4)2S2O3) as salting-out media for the extraction of chloramphenicol and tetracycline from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at atmospheric pressure (0.1 MPa) and 298.2 K. Partition coefficients of chloramphenicol and tetracycline between the two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. This paper is the first report to demonstrate the ability of the ATPS based on ethyl lactate to efficiently separate antibiotics. Thus, ATPS based on ethyl lactate represents a new and green platform for the extraction of antibiotics from aqueous solutions which can facilitate their detection, identification and quantification in surface waters as well as their extraction from fermentation broths.
AB - Ethyl lactate is a hydrophilic solvent produced from bio-renewable sources (bioethanol and lactic acid produced from corn fermentation) that is considered as a “green” solvent due to its extremely low toxicity, biodegradability and negligible eco-toxicity. This work focuses on the utilization of ethyl lactate to form aqueous two-phase systems (ATPS) in the presence of inorganic salts for the extraction of antibiotics from aqueous solutions. The performance of three thiosulfate salts (Na2S2O3, K2S2O3 and (NH4)2S2O3) as salting-out media for the extraction of chloramphenicol and tetracycline from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at atmospheric pressure (0.1 MPa) and 298.2 K. Partition coefficients of chloramphenicol and tetracycline between the two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. This paper is the first report to demonstrate the ability of the ATPS based on ethyl lactate to efficiently separate antibiotics. Thus, ATPS based on ethyl lactate represents a new and green platform for the extraction of antibiotics from aqueous solutions which can facilitate their detection, identification and quantification in surface waters as well as their extraction from fermentation broths.
KW - antibiotic extraction
KW - ATPS
KW - environmental monitoring
KW - liquid-liquid equilibria
UR - http://www.scopus.com/inward/record.url?scp=85104148626&partnerID=8YFLogxK
U2 - 10.1016/j.fluid.2021.113022
DO - 10.1016/j.fluid.2021.113022
M3 - Article
AN - SCOPUS:85104148626
VL - 539
JO - Fluid Phase Equilibria
JF - Fluid Phase Equilibria
SN - 0378-3812
M1 - 113022
ER -
