TY - JOUR
T1 - Extra-cellular vesicles carry proteome of cancer hallmarks
AU - Carvalho, Ana Sofia
AU - Baeta, Henrique
AU - Silva, Bruno Costa
AU - Moraes, Maria Carolina Strano
AU - Bodo, Cristian
AU - Beck, Hans Christian
AU - Rodriguez, Manuel S.
AU - Saraswat, Mayank
AU - Pandey, Akhilesh
AU - Matthiesen, Rune
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.
AB - Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.
UR - http://www.scopus.com/inward/record.url?scp=85072941462&partnerID=8YFLogxK
U2 - 10.2741/4811
DO - 10.2741/4811
M3 - Article
C2 - 31585894
AN - SCOPUS:85072941462
SN - 1093-4715
VL - 25
SP - 398
EP - 436
JO - Frontiers in bioscience (Landmark edition)
JF - Frontiers in bioscience (Landmark edition)
ER -
