Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant

Imen Hammami, Sílvia Rodrigues Gavinho, Ana Sofia Pádua, Maria do Carmo Lança, João Paulo Borges, Jorge Carvalho Silva, Isabel Sá-Nogueira, Suresh Kumar Jakka, Manuel Pedro Fernandes Graça

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
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Abstract

Dental implants have emerged as one of the most consistent and predictable treatments in the oral surgery field. However, the placement of the implant is sometimes associated with bacterial infection leading to its loss. In this work, we intend to solve this problem through the development of a biomaterial for implant coatings based on 45S5 Bioglass® modified with different amounts of niobium pentoxide (Nb2O5). The structural feature of the glasses, assessed by XRD and FTIR, did not change in spite of Nb2O5 incorporation. The Raman spectra reveal the Nb2O5 incorporation related to the appearance of NbO4 and NbO6 structural units. Since the electrical characteristics of these biomaterials influence their osseointegration ability, AC and DC electrical conductivity were studied by impedance spectroscopy, in the frequency range of 102–106 Hz and temperature range of 200–400 K. The cytotoxicity of glasses was evaluated using the osteosarcoma Saos-2 cells line. The in vitro bioactivity studies and the antibacterial tests against Gram-positive and Gram-negative bacteria revealed that the samples loaded with 2 mol% Nb2O5 had the highest bioactivity and greatest antibacterial effect. Overall, the results showed that the modified 45S5 bioactive glasses can be used as an antibacterial coating material for implants, with high bioactivity, being also non-cytotoxic to mammalian cells.

Original languageEnglish
Article number5244
Number of pages20
JournalInternational Journal of Molecular Sciences
Volume24
Issue number6
DOIs
Publication statusPublished - 9 Mar 2023

Keywords

  • antibacterial properties
  • bioactivity
  • Bioglass
  • biomaterial
  • bone regeneration
  • cytotoxicity
  • electrical properties
  • niobium oxide
  • osseointegration

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