Expression of Chikungunya virus-like particles

R. A. Velez, António Pedro Alves De Matos, Ricardo Manuel Soares Parreira, João Mário Brás da Piedade, B. Matos, C. Correia, Aida Maria da Conceição Esteves Simões

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disabling polyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent. Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. One approach to reduce the CHIKV burden is the development of a vaccine. Virus-like particles (VLPs) are a safe and highly effective class of subunit vaccines that mimic the overall structure of virus particles. Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation.
Original languageEnglish
Pages (from-to)59-60
JournalMicroscopy and Microanalysis
Volume18
Issue numberS5
DOIs
Publication statusPublished - 1 Jan 2012

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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