Exploring the potential of magnetic antimicrobial agents for water disinfection

Ana S Pina, Iris L Batalha, Cláudia S M Fernandes, Matheus A Aoki, Ana C A Roque

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalWater Research
Volume66
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Anti-Infective Agents
  • Nanoparticles
  • Polyethylene Glycols
  • Water Purification
  • Journal Article
  • Research Support, Non-U.S. Gov't

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