Exploring the potential of magnetic antimicrobial agents for water disinfection

Ana S Pina; Iris L Batalha; Cláudia S M Fernandes; Matheus A Aoki; Ana C A Roque

doi:10.1016/j.watres.2014.08.024

Exploring the potential of magnetic antimicrobial agents for water disinfection

Ana S Pina, Iris L Batalha, Cláudia S M Fernandes, Matheus A Aoki, Ana C A Roque

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.

Original language	English
Pages (from-to)	160-168
Number of pages	9
Journal	Water Research
Volume	66
DOIs	https://doi.org/10.1016/j.watres.2014.08.024
Publication status	Published - 1 Dec 2014

Keywords

Anti-Infective Agents
Nanoparticles
Polyethylene Glycols
Water Purification
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.watres.2014.08.024Licence: CC BY-NC-ND

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abstract = "Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.",

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AU - Pina, Ana S

AU - Batalha, Iris L

AU - Fernandes, Cláudia S M

AU - Aoki, Matheus A

AU - Roque, Ana C A

N1 - Sem pdf conforme despacho. Fundacao para a Ciencia e a Tecnologia - PEst-C/EQB/LA0006/2013 ; PTDC/EBB-BIO/102163/2008 ; PTDC/EBB-BIO/098961/2008 ; PTDC/EBB-BIO/118317/2010 ; SFRH/BPD/97585/20013 ; SFRH/BD/64427/2009

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N2 - Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.

AB - Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.

KW - Anti-Infective Agents

KW - Nanoparticles

KW - Polyethylene Glycols

KW - Water Purification

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1016/j.watres.2014.08.024

M3 - Article

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SN - 0043-1354

VL - 66

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EP - 168

JO - Water Research

JF - Water Research

ER -

Exploring the potential of magnetic antimicrobial agents for water disinfection

Abstract

Keywords

UN SDGs

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