Exploring the phytochemicals of acacia melanoxylon R. Br

Diana Alves, Sidónio Duarte, Pedro Arsénio, Joana Gonçalves, Cecília M. P. Rodrigues, Ana Lourenço, Patrícia Máximo

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Invasive species are currently a world menace to the environment, although the study of their chemistry may provide a means for their future beneficial use. From a study of Portuguese Acacia melanoxylon R. Br. five known compounds were isolated: lupeol, 3β-Z-coumaroyl lupeol, 3β-E-coumaroyl lupeol (dioslupecin A), kolavic acid 15-methyl ester and vomifoliol (blumenol A). Their structures were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry, and as a result some corrections are made to their previous13 C NMR assignments. Cytotoxicity of 3β-E-coumaroyl lupeol (dioslupecin A) and kolavic acid 15-methyl ester was evaluated against HCT116 human colorectal cancer cells although biological activity was not evident.

Original languageEnglish
Article number2698
Issue number12
Publication statusPublished - 8 Dec 2021


  • Acacia melanoxylon
  • Cytotoxicity
  • HCT116 human colorectal cancer cells
  • Invasive species
  • Terpenoids


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