Exploring the benefits of cellular models to uncover bioactive polyphenols for neurodegeneration

Rita Rosado-Ramos, Joana Godinho-Pereira, Inês Figueira, Carolina Jardim, Gonçalo Garcia, Regina Menezes

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Our society is currently experiencing increased lifespan; one of the top causes for the high incidence of neurodegenerative disorders. The lack of effective treatments delaying or blocking disease progression has encouraged the active search for novel therapies. Many evidences support the protective role of phytochemicals in the prevention of neurodegenerative diseases, particularly (poly)phenols. In this review, we described the use of cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for bioactive molecules, particularly (poly)phenols. Studies to assess the biological activity of (poly)phenols involve experimentation with in vitro and in vivo systems. In vitro systems are a useful tool as a first approach to test the underlined molecular mechanisms of candidate molecules. They can provide valuable information about biological activity, which can be then used to design animal and human intervention studies.

Original languageEnglish
Pages (from-to)2076-2106
Number of pages31
JournalCurrent Pharmaceutical Design
Volume24
Issue number19
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • 2D and 3D cells models
  • Neurodegenerative diseases
  • Oxidative stress
  • Phytochemicals
  • Polyphenol
  • Yeast

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