Exploring substrate interaction in respiratory alternative complex III from Rhodothermus marinus

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Abstract

Rhodothermus marinus is a thermohalophilic organism that has optimized its microaerobic metabolism at 65 °C. We have been exploring its respiratory chain and observed the existence of a quinone:cytochrome c oxidoreductase complex, named Alternative Complex III, structurally different from the bc1 complex. In the present work, we took profit from nanodiscs and liposomes technology to investigate ACIII activity in membrane-mimicking systems. In addition, we studied the interaction of ACIII with menaquinone, its potential electron acceptors (HiPIP and cytochrome c) and the caa3 oxygen reductase.

Original languageEnglish
Article number148983
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1864
Issue number3
DOIs
Publication statusPublished - 1 Aug 2023

Keywords

  • Alternative complex III (ACIII)
  • Cytochrome bc1
  • High Potential Iron Sulfur Protein (HiPIP)
  • Menaquinone
  • Respiratory chain
  • Thermophile

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