Exploiting microwave-assisted neat procedures: synthesis of N-aryl and N-alkylnitrones and their cycloaddition en route for isoxazolidines

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Abstract

Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of alpha-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate. (c) 2008 Elsevier Ltd. All rights reserved.
Original languageUnknown
Pages (from-to)10521-10530
JournalTetrahedron
Volume64
Issue number46
DOIs
Publication statusPublished - 1 Jan 2008

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