Exploiting microwave-assisted neat procedures: synthesis of N-aryl and N-alkylnitrones and their cycloaddition en route for isoxazolidines

Maria Teresa Barros; Marta Morais Saraiva de Andrade

doi:10.1016/j.tet.2008.08.101

Exploiting microwave-assisted neat procedures: synthesis of N-aryl and N-alkylnitrones and their cycloaddition en route for isoxazolidines

Maria Teresa Barros, Marta Morais Saraiva de Andrade

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of alpha-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate. (c) 2008 Elsevier Ltd. All rights reserved.

Original language	Unknown
Pages (from-to)	10521-10530
Journal	Tetrahedron
Volume	64
Issue number	46
DOIs	https://doi.org/10.1016/j.tet.2008.08.101
Publication status	Published - 1 Jan 2008

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10.1016/j.tet.2008.08.101

Cite this

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abstract = "Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of alpha-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate. (c) 2008 Elsevier Ltd. All rights reserved.",

keywords = "PBN, Neat reactions, Microwave, 1,3-Dipolar cycloaddition, Nitrone",

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AB - Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of alpha-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate. (c) 2008 Elsevier Ltd. All rights reserved.

KW - PBN

KW - Neat reactions

KW - Microwave

KW - 1,3-Dipolar cycloaddition

KW - Nitrone

U2 - 10.1016/j.tet.2008.08.101

DO - 10.1016/j.tet.2008.08.101

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