Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation

1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

C. Ramos, P. Napoleão, C. Fondinho, M. Selas, M. Mota Carmo, R. Cruz Ferreira, T. Pinheiro, Control and Communication (INSTICC); MedinRes - Medical Information and Research Institute for Systems and Technologies of; Information

Research output: Contribution to conferencePaper

Abstract

The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.
Original languageEnglish
Pages90-94
Number of pages5
Publication statusPublished - 2013

Fingerprint

Atherosclerotic Plaques
Technology
Growth
Coronary Artery Disease
Pathologic Constriction
Biomarkers
Inflammation
oxidized low density lipoprotein
low density lipoprotein inhibitor
Serum
Therapeutics

Keywords

  • Biomarkers
  • Expansive Plaque
  • Plaque Vulnerability
  • VH-IVUS
  • Atherosclerotic plaque
  • Coronary artery disease
  • Disease severity
  • Oxidative modification
  • Vulnerable plaques
  • Diagnosis

Cite this

Ramos, C., Napoleão, P., Fondinho, C., Selas, M., Mota Carmo, M., Cruz Ferreira, R., ... Institute for Systems and Technologies of; Information, C. A. C. INSTICC. M. . M. I. A. R. (2013). Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 90-94.
Ramos, C. ; Napoleão, P. ; Fondinho, C. ; Selas, M. ; Mota Carmo, M. ; Cruz Ferreira, R. ; Pinheiro, T. ; Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research. / Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation : 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 5 p.
@conference{2f797cc2412d400b91be1d65d73131b5,
title = "Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013",
abstract = "The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.",
keywords = "Biomarkers, Expansive Plaque, Plaque Vulnerability, VH-IVUS, Atherosclerotic plaque, Coronary artery disease, Disease severity, Oxidative modification, Vulnerable plaques, Diagnosis",
author = "C. Ramos and P. Napole{\~a}o and C. Fondinho and M. Selas and {Mota Carmo}, M. and {Cruz Ferreira}, R. and T. Pinheiro and {Institute for Systems and Technologies of; Information}, {Control and Communication (INSTICC); MedinRes - Medical Information and Research}",
year = "2013",
language = "English",
pages = "90--94",

}

Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation : 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. / Ramos, C.; Napoleão, P.; Fondinho, C.; Selas, M.; Mota Carmo, M.; Cruz Ferreira, R.; Pinheiro, T.; Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research.

2013. 90-94.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation

T2 - 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

AU - Ramos, C.

AU - Napoleão, P.

AU - Fondinho, C.

AU - Selas, M.

AU - Mota Carmo, M.

AU - Cruz Ferreira, R.

AU - Pinheiro, T.

AU - Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research

PY - 2013

Y1 - 2013

N2 - The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.

AB - The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.

KW - Biomarkers

KW - Expansive Plaque

KW - Plaque Vulnerability

KW - VH-IVUS

KW - Atherosclerotic plaque

KW - Coronary artery disease

KW - Disease severity

KW - Oxidative modification

KW - Vulnerable plaques

KW - Diagnosis

M3 - Paper

SP - 90

EP - 94

ER -