Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

C. Ramos, P. Napoleão, C. Fondinho, M. Selas, M. Mota Carmo, R. Cruz Ferreira, T. Pinheiro, Control and Communication (INSTICC); MedinRes - Medical Information and Research Institute for Systems and Technologies of; Information

Research output: Contribution to conferencePaper

Abstract

The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.
Original languageEnglish
Pages90-94
Number of pages5
Publication statusPublished - 2013

Keywords

  • Biomarkers
  • Expansive Plaque
  • Plaque Vulnerability
  • VH-IVUS
  • Atherosclerotic plaque
  • Coronary artery disease
  • Disease severity
  • Oxidative modification
  • Vulnerable plaques
  • Diagnosis

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    Ramos, C., Napoleão, P., Fondinho, C., Selas, M., Mota Carmo, M., Cruz Ferreira, R., ... Institute for Systems and Technologies of; Information, C. A. C. INSTICC. M. . M. I. A. R. (2013). Expansive growth of atherosclerotic plaques assessed by VH-IVUS: Association with TNF-α and OX-LDL levels in circulation: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 90-94.