Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism

Sara Branco, Hélène Badouin, Ricardo C. Rodríguez De La Vega, Jéröme Gouzy, Fantin Carpentier, Gabriela Aguileta, Sophie Siguenza, Jean Tristan Brandenburg, Marco A. Coelho, Michael E. Hood, Tatiana Giraud

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29 Citations (Scopus)

Abstract

Sex chromosomes can display successive steps of recombination suppression known as "evolutionary strata," which are thought to result from the successive linkage of sexually antagonistic genes to sex-determining genes. However, there is little evidence to support this explanation. Here we investigate whether evolutionary strata can evolve without sexual antagonism using fungi that display suppressed recombination extending beyond loci determining mating compatibility despite lack of male/female roles associated with their mating types. By comparing full-length chromosome assemblies from five anther-smut fungi with or without recombination suppression in their mating-type chromosomes, we inferred the ancestral gene order and derived chromosomal arrangements in this group. This approach shed light on the chromosomal fusion underlying the linkage of mating-type loci in fungi and provided evidence for multiple clearly resolved evolutionary strata over a range of ages (0.9-2.1 million years) in mating-type chromosomes. Several evolutionary strata did not include genes involved in mating-type determination. The existence of strata devoid of matingtype genes, despite the lack of sexual antagonism, calls for a unified theory of sex-related chromosome evolution, incorporating, for example, the influence of partially linked deleterious mutations and the maintenance of neutral rearrangement polymorphism due to balancing selection on sexes and mating types.

Original languageEnglish
Pages (from-to)7067-7072
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number27
DOIs
Publication statusPublished - 3 Jul 2017

Keywords

  • Chromosomal rearrangements
  • Evolutionary strata
  • Fungi
  • Genomic degeneration
  • Mating-type chromosomes

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    Branco, S., Badouin, H., Rodríguez De La Vega, R. C., Gouzy, J., Carpentier, F., Aguileta, G., Siguenza, S., Brandenburg, J. T., Coelho, M. A., Hood, M. E., & Giraud, T. (2017). Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7067-7072. https://doi.org/10.1073/pnas.1701658114