Evolution of MRSA during hospital transmission and intercontinental spread

Simon R. Harris, Edward J. Feil, Matthew T G Holden, Quail, Michael A., Nickerson, Emma K., Chantratita, Narisara, Susana Maria Gardete, A. Tavares , Day, Nick, Lindsay, Jodie A., Jonathan D. Edgeworth, H. de Lencastre, Julian Parkhill, Sharon J. Peacock, Stephen D. Bentley

Research output: Contribution to journalArticlepeer-review


Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.
Original languageEnglish
Pages (from-to)469-474
Number of pages5
VolumeVol. 327
Issue numbern.º 5964
Publication statusPublished - 22 Jan 2010


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