Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection

Sepehr Talebian; Fariba Dehghani; Paul S. Weiss; João Conde

doi:10.1016/j.tibtech.2023.07.004

Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection

Sepehr Talebian, Fariba Dehghani, Paul S. Weiss, João Conde

Research output: Contribution to journal › Short survey › peer-review

3 Citations (Scopus)

Abstract

CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an invaluable asset that can ultimately facilitate accurate diagnoses of biologically complex diseases.

Original language	English
Pages (from-to)	10 - 13
Journal	Trends In Biotechnology
Volume	42
Issue number	1
Early online date	27 Jul 2023
DOIs	https://doi.org/10.1016/j.tibtech.2023.07.004
Publication status	Published - Jan 2024

Keywords

amplification-free
biosensing
CRISPR/Cas
nucleic acid detection

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10.1016/j.tibtech.2023.07.004

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title = "Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection",

abstract = "CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an invaluable asset that can ultimately facilitate accurate diagnoses of biologically complex diseases.",

keywords = "amplification-free, biosensing, CRISPR/Cas, nucleic acid detection",

author = "Sepehr Talebian and Fariba Dehghani and Weiss, {Paul S.} and Jo{\~a}o Conde",

note = "Funding Information: J.C. acknowledges the European Research Council Starting Grant ( ERC-StG-2019-848325 ). F.D. acknowledges financial support from the Australian Research Council (ARC) through an ARC linkage grant ( ARC LP190100143 ). Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

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AU - Dehghani, Fariba

AU - Weiss, Paul S.

AU - Conde, João

N1 - Funding Information: J.C. acknowledges the European Research Council Starting Grant ( ERC-StG-2019-848325 ). F.D. acknowledges financial support from the Australian Research Council (ARC) through an ARC linkage grant ( ARC LP190100143 ). Publisher Copyright: © 2023 Elsevier Ltd

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AB - CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an invaluable asset that can ultimately facilitate accurate diagnoses of biologically complex diseases.

KW - amplification-free

KW - biosensing

KW - CRISPR/Cas

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Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection

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Keywords

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