Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection

Sepehr Talebian, Fariba Dehghani, Paul S. Weiss, João Conde

Research output: Contribution to journalShort surveypeer-review

Abstract

CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an invaluable asset that can ultimately facilitate accurate diagnoses of biologically complex diseases.

Original languageEnglish
JournalTrends In Biotechnology
DOIs
Publication statusE-pub ahead of print - 27 Jul 2023

Keywords

  • amplification-free
  • biosensing
  • CRISPR/Cas
  • nucleic acid detection

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