Abstract
Two new tetracyclic diterpene polyesters, euphoportlandols A (1) and B (2), have been isolated along with 12 known tetracyclic triterpenes from an acetone extract of Euphorbia portlandica. Their structures were established as 5α,11α,-14α,17-tetraacetoxy-3β-benzoyloxy-6β, 15β-dihydroxy-9-oxoseget-8(12)-ene (1) and 5α,11α,14α,17- tetraacetoxy-3β-benzoyloxy-6β,15β-dihydroxy-9-oxosegetane (2), respectively, by spectroscopic data interpretation. Compounds 1 and 2 were evaluated for their ability to inhibit multidrug resistance in cancer cells. Both compounds were found to be inhibitors of P-glycoprotein activity.
| Original language | English |
|---|---|
| Pages (from-to) | 950-953 |
| Number of pages | 4 |
| Journal | Journal Of Natural Products |
| Volume | 69 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Diterpenes
- Drug Resistance, Multiple
- Euphorbia
- Mice
- Molecular Conformation
- Molecular Structure
- P-Glycoprotein
- Plants, Medicinal
- Polyesters
- Portugal
- Triterpenes
- Tumor Cells
- Cultured
- Verapamil
- Euphorbia portlandica
Fingerprint
Dive into the research topics of 'Euphoportlandols A and B, tetracylic diterpene polyesters from Euphorbia portlandica and their anti-MDR effects in cancer cells'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver