TY - JOUR
T1 - Essential Trace Elements Status in Portuguese Pregnant Women and Their Association with Maternal and Neonatal Outcomes
T2 - A Prospective Study from the IoMum Cohort
AU - Bracchi, Isabella
AU - Guimarães, Juliana
AU - Rodrigues, Catarina
AU - Azevedo, Rui
AU - Coelho, Cláudia Matta
AU - Pinheiro, Cátia
AU - Morais, Juliana
AU - Barreiros-Mota, Inês
AU - Fernandes, Virgínia Cruz
AU - Delerue-Matos, Cristina
AU - Pinto, Edgar
AU - Moreira-Rosário, André
AU - de Azevedo, Luís Filipe Ribeiro
AU - Dias, Cláudia Camila
AU - Lima, Jorge
AU - Sapinho, Inês
AU - Ramalho, Carla
AU - Calhau, Conceição
AU - Leite, João Costa
AU - Almeida, Agostinho
AU - Pestana, Diogo
AU - Keating, Elisa
PY - 2023/10/21
Y1 - 2023/10/21
N2 - Cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association with pregnancy outcomes. First trimester pregnant women of Porto and Lisbon provided a random spot urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). A total of 635 mother:child pairs were included. Having urinary Zn levels above the 50th percentile (P50) was an independent risk factor for pre-eclampsia (PE) (aOR [95% CI]: 5.350 [1.044-27.423], p = 0.044). Urinary Zn levels above the P50 decreased the risk of small for gestational age (SGA) birth head circumference (aOR [95% CI]: 0.315 [0.113-0.883], p = 0.028), but it increased the risk SGA length (aOR [95% CI]: 2.531 [1.057-6.062], p = 0.037). This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant women.
AB - Cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association with pregnancy outcomes. First trimester pregnant women of Porto and Lisbon provided a random spot urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). A total of 635 mother:child pairs were included. Having urinary Zn levels above the 50th percentile (P50) was an independent risk factor for pre-eclampsia (PE) (aOR [95% CI]: 5.350 [1.044-27.423], p = 0.044). Urinary Zn levels above the P50 decreased the risk of small for gestational age (SGA) birth head circumference (aOR [95% CI]: 0.315 [0.113-0.883], p = 0.028), but it increased the risk SGA length (aOR [95% CI]: 2.531 [1.057-6.062], p = 0.037). This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant women.
KW - essential trace elements
KW - neonatal anthropometry
KW - neonatal outcomes
KW - pre-eclampsia
KW - pregnancy
KW - pregnancy complications
U2 - 10.3390/biology12101351
DO - 10.3390/biology12101351
M3 - Article
C2 - 37887061
SN - 2079-7737
VL - 12
JO - Biology
JF - Biology
IS - 10
M1 - 1351
ER -
