Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal

Marta Aires-de-sousa, José Manuel Ortiz De La Rosa, Maria Luísa Gonçalves, Ana Luísa Pereira, Patrice Nordmann, Laurent Poirel

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22 Citations (Scopus)


We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013-2018 in a 123-bed hospital in Lisbon. We identified blaKPC-3 (n = 36), blaOXA-181 (n = 9), and blaGES-5 (n = 8) carbapenemase genes and observed co-occurrence of blaKPC-3 and blaGES-5 in 7 isolates. A single GES-5-producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co-located on the same ColE1-like plasmid. The blaOXA-181 gene was always located on an IncX3 plasmid, whereas blaKPC-3 was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L).

Original languageEnglish
Pages (from-to)1632-1638
JournalEmerging Infectious Diseases
Issue number9
Publication statusPublished - 1 Sep 2019


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