Epidemiology of Bloodstream infection in Portuguese Neonatal Intensive Care Units

Research output: Contribution to conferencePaper


Objective: To know the epidemiology of bloodstream in- fection in newborn infants admitted to Portuguese NlCUs. Methods: All patients in the National Registry, admitted from January 2008 to December 2015, with sepsis, meningitis, necrotizing enterocolitis and pneumonia with positive blood or cerebrospinal fluid cultures were enrolled. Results: There were 40.205 registrations with 2906 positive cultures in 2352 newborn infants accounting for 2593 episodes of infection (10.9 episodes of infection/ 1000 admission days). The median gestational age and birth weight were 30 weeks (22-42) and 1300g (416-5270) ; 55.2% were male; 2273 episodes were sepsis, 121 sepsis with meningitis, I 03 necrotizing enterocolitis with sepsis, 95 sepsis with pneumonia and I sepsis with meningitis and pneumonia; 433 (16.7%) episodes were classified as early- onset, 1742 (67.2%) as late-onset and 418 as post-neonatal infections. There were 141 deaths caused by infection (lethality 6%). Five cultures grew two different strains - total of strains 2598. The most frequent isolates were coagulase negative Staphylococcus (91.2% resistant to methicillin, 81.4% resistant to gentamicin); S. aureus (25.3% resistant to methicillin); E.coli (68.9% resistant to ampicillin); group B Streptococcus; Klebsiella spp. (44.4% resistant to cefotaxime and 33.3% gentamicin) ; 41% of Enterobacter spp. were resistant to cefotaxime; 1551 episodes of infection (with peripheral and/or central venous catheter (eVC) positive blood culture) occurred i n
newborn infants with a eve-rate of infection in patients with eve 10.411000 eve days. Conclusions: Concerning type of infection and microorganisms, findings are in the range of expected; bacterial resistance is a cause of concern as well as the rate of infection in newborn infants with CVC.

Original languageEnglish
Publication statusPublished - 2017
EventEuropean Workshop on Neonatology - Germany, Westerburg, Germany
Duration: 28 May 201731 May 2017
Conference number: 25th


WorkshopEuropean Workshop on Neonatology


Dive into the research topics of 'Epidemiology of Bloodstream infection in Portuguese Neonatal Intensive Care Units'. Together they form a unique fingerprint.

Cite this