Abstract
Objective: To know the epidemiology of bloodstream infection
in newborn infants admitted to Portuguese NICUs.
Methods: All patients in the National Registry, admitted
from January 2008 to December 2015, with sepsis,
meningitis, necrotizing enterocolitis and pneumonia with
positive blood or cerebrospinal fl uid cultures were
enrolled.
Results: There were 40.205 registrations with 2906
positive cultures in 2352 newborn infants accounting for
2593 episodes of infection (10.9 episodes of infection/1000
admission days). The median gestational age and birth
weight were 30 weeks (22-42) and 1300g (416-5270);
55.2% were male; 2273 episodes were sepsis, 121 sepsis
with meningitis, 103 necrotizing enterocolitis with sepsis,
95 sepsis with pneumonia and 1 sepsis with meningitis and
pneumonia; 433 (16.7%) episodes were classifi ed as earlyonset,
1742 (67.2%) as late-onset and 418 as post-neonatal
infections. There were 141 deaths caused by infection
(lethality 6%). Five cultures grew two different strains –
total of strains 2598. The most frequent isolates were
coagulase negative Staphylococcus (91.2% resistant to
methicillin, 81.4% resistant to gentamicin); S. aureus
(25.3% resistant to methicillin); E.coli (68.9% resistant to
ampicillin); group B Streptococcus; Klebsiella spp.
(44.4% resistant to cefotaxime and 33.3% gentamicin);
41% of Enterobacter spp. were resistant to cefotaxime;
1551 episodes of infection (with peripheral and/or central
venous catheter (CVC) positive blood culture) occurred in
newborn infants with a CVC-rate of infection in patients
with CVC 10.4/1000 CVC days.
Conclusions: Concerning type of infection and
microorganisms, fi ndings are in the range of expected;
bacterial resistance is a cause of concern as well as the rate
of infection in newborn infants with CVC.
in newborn infants admitted to Portuguese NICUs.
Methods: All patients in the National Registry, admitted
from January 2008 to December 2015, with sepsis,
meningitis, necrotizing enterocolitis and pneumonia with
positive blood or cerebrospinal fl uid cultures were
enrolled.
Results: There were 40.205 registrations with 2906
positive cultures in 2352 newborn infants accounting for
2593 episodes of infection (10.9 episodes of infection/1000
admission days). The median gestational age and birth
weight were 30 weeks (22-42) and 1300g (416-5270);
55.2% were male; 2273 episodes were sepsis, 121 sepsis
with meningitis, 103 necrotizing enterocolitis with sepsis,
95 sepsis with pneumonia and 1 sepsis with meningitis and
pneumonia; 433 (16.7%) episodes were classifi ed as earlyonset,
1742 (67.2%) as late-onset and 418 as post-neonatal
infections. There were 141 deaths caused by infection
(lethality 6%). Five cultures grew two different strains –
total of strains 2598. The most frequent isolates were
coagulase negative Staphylococcus (91.2% resistant to
methicillin, 81.4% resistant to gentamicin); S. aureus
(25.3% resistant to methicillin); E.coli (68.9% resistant to
ampicillin); group B Streptococcus; Klebsiella spp.
(44.4% resistant to cefotaxime and 33.3% gentamicin);
41% of Enterobacter spp. were resistant to cefotaxime;
1551 episodes of infection (with peripheral and/or central
venous catheter (CVC) positive blood culture) occurred in
newborn infants with a CVC-rate of infection in patients
with CVC 10.4/1000 CVC days.
Conclusions: Concerning type of infection and
microorganisms, fi ndings are in the range of expected;
bacterial resistance is a cause of concern as well as the rate
of infection in newborn infants with CVC.
| Original language | English |
|---|---|
| Pages | 214-214 |
| Number of pages | 1 |
| Publication status | Published - 2017 |
| Event | European Workshop on Neonatology - Germany, Westerburg, Germany Duration: 28 May 2017 → 31 May 2017 Conference number: 25th |
Workshop
| Workshop | European Workshop on Neonatology |
|---|---|
| Country/Territory | Germany |
| City | Westerburg, |
| Period | 28/05/17 → 31/05/17 |