Epidemiology of blood-stream infection in portuguese neonatal intensive care units

Neto MT, Alexandra Almeida

Research output: Contribution to conferenceAbstract


Objective: To know the epidemiology of bloodstream infection
in newborn infants admitted to Portuguese NICUs.
Methods: All patients in the National Registry, admitted
from January 2008 to December 2015, with sepsis,
meningitis, necrotizing enterocolitis and pneumonia with
positive blood or cerebrospinal fl uid cultures were
Results: There were 40.205 registrations with 2906
positive cultures in 2352 newborn infants accounting for
2593 episodes of infection (10.9 episodes of infection/1000
admission days). The median gestational age and birth
weight were 30 weeks (22-42) and 1300g (416-5270);
55.2% were male; 2273 episodes were sepsis, 121 sepsis
with meningitis, 103 necrotizing enterocolitis with sepsis,
95 sepsis with pneumonia and 1 sepsis with meningitis and
pneumonia; 433 (16.7%) episodes were classifi ed as earlyonset,
1742 (67.2%) as late-onset and 418 as post-neonatal
infections. There were 141 deaths caused by infection
(lethality 6%). Five cultures grew two different strains –
total of strains 2598. The most frequent isolates were
coagulase negative Staphylococcus (91.2% resistant to
methicillin, 81.4% resistant to gentamicin); S. aureus
(25.3% resistant to methicillin); E.coli (68.9% resistant to
ampicillin); group B Streptococcus; Klebsiella spp.
(44.4% resistant to cefotaxime and 33.3% gentamicin);
41% of Enterobacter spp. were resistant to cefotaxime;
1551 episodes of infection (with peripheral and/or central
venous catheter (CVC) positive blood culture) occurred in
newborn infants with a CVC-rate of infection in patients
with CVC 10.4/1000 CVC days.
Conclusions: Concerning type of infection and
microorganisms, fi ndings are in the range of expected;
bacterial resistance is a cause of concern as well as the rate
of infection in newborn infants with CVC.
Original languageEnglish
Number of pages1
Publication statusPublished - 2017
EventEuropean Workshop on Neonatology - Germany, Westerburg, Germany
Duration: 28 May 201731 May 2017
Conference number: 25th


WorkshopEuropean Workshop on Neonatology


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