Epidemiology and clinical presentation of community-acquired Staphylococcus aureus bacteraemia in children under 5 years of age admitted to the Manhica District Hospital, Mozambique, 2001-2019

M Garrine, L Quinto, SS Costa, A Messa, AJ Massinga, D Vubil, T Nhampossa, S Massora, S Acacio, A Cossa, B Sigauque, Q Bassat, I Couto, I Mandomando

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Abstract

Staphylococcus aureus bacteraemia (SAB) is one of the most common bloodstream infections globally. Data on the burden and
epidemiology of community-acquired SAB in low-income countries are scarce but needed to defne preventive and management
strategies. Blood samples were collected from children<5 years of age with fever or severe disease admitted to the Manhiça District
Hospital for bacterial isolation, including S. aureus. Between 2001 and 2019, 7.6% (3,197/41,891) of children had bacteraemia, of
which 12.3% corresponded to SAB. The overall incidence of SAB was 56.1 episodes/100,000 children-years at risk (CYAR), being
highest among neonates (589.8 episodes/100,000 CYAR). SAB declined signifcantly between 2001 and 2019 (322.1 to 12.5 episodes/100,000 CYAR). In-hospital mortality by SAB was 9.3% (31/332), and signifcantly associated with infections by multidrugresistant (MDR) strains (14.7%, 11/75 vs. 6.9%, 14/204 among non-MDR, p=0.043) and methicillin-resistant S. aureus (33.3%,
5/15 vs. 7.6%, 20/264 among methicillin-susceptible S. aureus, p=0.006). Despite the declining rates of SAB, this disease remains
an important cause of death among children admitted to MDH, possibly in relation to the resistance to the frst line of empirical
treatment in use in our setting, suggesting an urgent need to review current policy recommendations
Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume42
Issue number5
DOIs
Publication statusPublished - 18 Mar 2023

Keywords

  • Bacteraemia
  • Epidemiology
  • Incidence
  • Paediatric
  • Staphylococcus aureus

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