Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes

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Abstract

Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative and easy catalyst regeneration. The strategy involved the synthesis of a template-monomer (T:M) complex followed by the crosslinked polymerization in supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP catalyst is obtained after the template cleavage from the matrix, and the oxidation of the N[sbnd]H groups turns available TEMPO moieties within the MIP. The oxidation of benzyl alcohol, 5α-cholestan-3β-ol and cholic acid was fast, in high yield and with selective oxidation capacity.

Original languageEnglish
Article number106537
Number of pages7
JournalCatalysis Communications
Volume172
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Artificial enzymes
  • Catalysis
  • Green chemistry
  • Molecular recognition
  • Molecularly imprinted polymers
  • TEMPO

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