TY - JOUR
T1 - Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
AU - Viveiros, Raquel
AU - Maia, Luísa B.
AU - Corvo, Marta C.
AU - Bonifácio, Vasco D. B.
AU - Heggie, William
AU - Casimiro, Teresa
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F32473%2F2017/PT#
info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBDE%2F51907%2F2012/PT#
Principal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis.
Publisher Copyright:
© 2022
PY - 2022/12
Y1 - 2022/12
N2 - Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative and easy catalyst regeneration. The strategy involved the synthesis of a template-monomer (T:M) complex followed by the crosslinked polymerization in supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP catalyst is obtained after the template cleavage from the matrix, and the oxidation of the N[sbnd]H groups turns available TEMPO moieties within the MIP. The oxidation of benzyl alcohol, 5α-cholestan-3β-ol and cholic acid was fast, in high yield and with selective oxidation capacity.
AB - Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative and easy catalyst regeneration. The strategy involved the synthesis of a template-monomer (T:M) complex followed by the crosslinked polymerization in supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP catalyst is obtained after the template cleavage from the matrix, and the oxidation of the N[sbnd]H groups turns available TEMPO moieties within the MIP. The oxidation of benzyl alcohol, 5α-cholestan-3β-ol and cholic acid was fast, in high yield and with selective oxidation capacity.
KW - Artificial enzymes
KW - Catalysis
KW - Green chemistry
KW - Molecular recognition
KW - Molecularly imprinted polymers
KW - TEMPO
UR - http://www.scopus.com/inward/record.url?scp=85140086589&partnerID=8YFLogxK
U2 - 10.1016/j.catcom.2022.106537
DO - 10.1016/j.catcom.2022.106537
M3 - Article
AN - SCOPUS:85140086589
SN - 1566-7367
VL - 172
JO - Catalysis Communications
JF - Catalysis Communications
M1 - 106537
ER -