TY - JOUR
T1 - Enzymatic Poly(octamethylene suberate) Synthesis by a Two-Step Polymerization Method Based on the New Greener Polymer-5B Technology
AU - Pfluck, Ana C.D.
AU - de Barros, Dragana P.C.
AU - Oliva, Abel
AU - Fonseca, Luis P.
N1 - Funding Information:
Funding: Funding was received by A.C.D.P. from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-Codigo de financiamento 001, Brazil, and the Institute for Bioengineering and Biosciences (iBB) from the Portuguese Foundation for Science and Technology (FCT; UID/BIO/04565/2013) and from the Programa Operacional Regional de Lisboa 2020 (project no. 007317). The contribution of D.P.C.d.B and A.O. was supported by iNOVA4Health —UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by FCT.
Funding Information:
was received by A.C.D.P. from the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)-Codigo de financiamento 001, Brazil, and the Institute for Bioengineering and Biosciences (iBB) from the Portuguese Foundation for Science and Technology (FCT; UID/BIO/04565/2013) and from the Programa Operacional Regional de Lisboa 2020 (project no. 007317). The contribution of D.P.C.d.B and A.O. was supported by iNOVA4Health ?UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by FCT.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2
Y1 - 2022/2
N2 - Here, we report a new two-step enzymatic polymerization strategy for the synthesis of poly(octamethylene suberate) (POS) using an immobilized Pseudozyma antarctica lipase B (IMM-PBLI). The strategy overcomes the lack of enzymatic POS synthesis in solvent-free systems and increases the final polymer molecular weight. In the first step, the direct polycondensation of suberic acid and 1,8-octanediol was catalyzed by IMM-PBLI at 45◦C, leading to the production of prepolymers with molecular weights (MWs) of 2800, 3400, and 4900 g mol−1 after 8 h in miniemulsion, water, and an organic solvent (cyclohexane: tetrahydrofuran 5:1 v/v), respectively. In the second polymerization step, wet prepolymers were incubated at 60 or 80◦C, at atmospheric pressure, in the presence of IMM-PBLI, and without stirring. The final POS polymers showed a significant increase in MW to 5000, 5800, and 19,800 g mol−1 (previously synthesized in miniemulsion, water, or organic solvent, respectively). FTIR analysis of the final polymers confirmed the successful POS synthesis and a high degree of monomer conversion. This innovative two-step polymerization strategy opens up a new opportunity for implementing greener and more environmentally friendly processes for synthesizing biodegradable polyesters.
AB - Here, we report a new two-step enzymatic polymerization strategy for the synthesis of poly(octamethylene suberate) (POS) using an immobilized Pseudozyma antarctica lipase B (IMM-PBLI). The strategy overcomes the lack of enzymatic POS synthesis in solvent-free systems and increases the final polymer molecular weight. In the first step, the direct polycondensation of suberic acid and 1,8-octanediol was catalyzed by IMM-PBLI at 45◦C, leading to the production of prepolymers with molecular weights (MWs) of 2800, 3400, and 4900 g mol−1 after 8 h in miniemulsion, water, and an organic solvent (cyclohexane: tetrahydrofuran 5:1 v/v), respectively. In the second polymerization step, wet prepolymers were incubated at 60 or 80◦C, at atmospheric pressure, in the presence of IMM-PBLI, and without stirring. The final POS polymers showed a significant increase in MW to 5000, 5800, and 19,800 g mol−1 (previously synthesized in miniemulsion, water, or organic solvent, respectively). FTIR analysis of the final polymers confirmed the successful POS synthesis and a high degree of monomer conversion. This innovative two-step polymerization strategy opens up a new opportunity for implementing greener and more environmentally friendly processes for synthesizing biodegradable polyesters.
KW - Aqueous media
KW - Bulk polymerization
KW - Enzymatic polycondensation
KW - Organic solvent media
KW - Two-step polymerization
UR - http://www.scopus.com/inward/record.url?scp=85123529536&partnerID=8YFLogxK
U2 - 10.3390/pr10020221
DO - 10.3390/pr10020221
M3 - Article
AN - SCOPUS:85123529536
SN - 2227-9717
VL - 10
JO - Processes
JF - Processes
IS - 2
M1 - 221
ER -