TY - JOUR
T1 - Enterovirus detection in stool samples from Mozambican children with acute gastroenteritis
AU - Bero, Diocreciano Matias
AU - da Silva, Edson Elias
AU - Júnior, Ivanildo Pedro de Sousa
AU - Nhassengo, Sheila António
AU - Machado, Raiana Scerni
AU - Bauhofer, Adilson Fernando Loforte
AU - Chilaúle, Jorfélia José
AU - Munlela, Benilde
AU - Guimarães, Esperança
AU - Cossa-Moiane, Idalécia
AU - Sambo, Júlia
AU - Anapakala, Elda
AU - Cassocera, Marta
AU - Coutinho-Manhique, Lena
AU - Chissaque, Assucênio
AU - Langa, Jerónimo S.
AU - Burlandy, Fernanda
AU - de Deus, Nilsa
N1 - Funding Information:
Diocreciano Bero, Ph.D. was supported by Brazilian National Council for Scientific and Technological Development and the Academy of Sciences for the Developing World (CNPq/TWAS, grant number 190,897/2015–5). The ViNaDia was sponsored by Gavi, the Vaccine Alliance through Centers for Disease Control and Prevention (CDC) , Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO), Deutsche Forschungsgemeinschaft (DFG, grant number JO369/5–1). Nilsa de Deus was fellowship of the European Foundation Initiative into African Research in Neglected Tropical Diseases (EFINTD, grant number 89,539).
Publisher Copyright:
© 2022
PY - 2023/2
Y1 - 2023/2
N2 - Enteroviruses (EV) are predominantly enteric viruses, present in all parts of the world causing disease in humans with a broad spectrum of clinical presentations. The purpose of this study was to identify non-polio enteroviruses (NPEV) in stool samples collected from children with acute gastroenteritis (AGE) symptoms of unknown etiology in four provinces (Maputo, Nampula, Sofala and Zambézia) of Mozambique. From June 2014 to March 2018, 327 stool samples were collected from children hospitalized with AGE in health care units. NPEVs were detected in 52 samples (52/327; 15.9%) and were more frequent in children under 5 years of age. The age group from 12 to 23 months was the most affected and showed more severity of disease. We also identified 26 different EV-types with the following detection pattern EV-B>EV-C>EV-A. The major EV-types were EV-A119 (9/52; 17.3%) and EV-C99 (8/52; 15.4%), accounting for 32.7% of the total. In addition to EV-A119, other uncommon EV-types were also identified, such as EV-B75, EV-B97 and EV-C113. The current study shows a high heterogeneity of EV types circulating in children with AGE in Mozambique as well as the identification of rarely described enteroviruses.
AB - Enteroviruses (EV) are predominantly enteric viruses, present in all parts of the world causing disease in humans with a broad spectrum of clinical presentations. The purpose of this study was to identify non-polio enteroviruses (NPEV) in stool samples collected from children with acute gastroenteritis (AGE) symptoms of unknown etiology in four provinces (Maputo, Nampula, Sofala and Zambézia) of Mozambique. From June 2014 to March 2018, 327 stool samples were collected from children hospitalized with AGE in health care units. NPEVs were detected in 52 samples (52/327; 15.9%) and were more frequent in children under 5 years of age. The age group from 12 to 23 months was the most affected and showed more severity of disease. We also identified 26 different EV-types with the following detection pattern EV-B>EV-C>EV-A. The major EV-types were EV-A119 (9/52; 17.3%) and EV-C99 (8/52; 15.4%), accounting for 32.7% of the total. In addition to EV-A119, other uncommon EV-types were also identified, such as EV-B75, EV-B97 and EV-C113. The current study shows a high heterogeneity of EV types circulating in children with AGE in Mozambique as well as the identification of rarely described enteroviruses.
KW - Children
KW - Diarrheal disease
KW - Enterovirus
KW - Gastroenteritis
KW - Mozambique
UR - http://www.scopus.com/inward/record.url?scp=85141944514&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2022.106755
DO - 10.1016/j.actatropica.2022.106755
M3 - Article
C2 - 36379257
AN - SCOPUS:85141944514
SN - 0001-706X
VL - 238
JO - Acta Tropica
JF - Acta Tropica
M1 - 106755
ER -
