Engineering gold nanoparticles for molecular diagnostics and biosensing

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20 Citations (Scopus)


Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials and nanoparticles with particular focus on their applications in biomedicine. In particular, gold nanoparticles (AuNPs) have been the focus of great interest, due to their exquisite intrinsic properties, such as ease of synthesis and surface functionalization, tunable size and shape, lack of acute toxicity and favorable optical, electronic, and physicochemical features, which possess great value for application in biodetection and diagnostics purposes, including molecular sensing, photoimaging, and application under the form of portable and simple biosensors (e.g., lateral flow immunoassays that have been extensively exploited during the current COVID-19 pandemic). We shall discuss the main properties of AuNPs, their synthesis and conjugation to biorecognition moieties, and the current trends in sensing and detection in biomedicine and diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
Original languageEnglish
Article numbere1836
Number of pages28
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number1
Early online date5 Aug 2022
Publication statusPublished - Feb 2023


  • biodetection
  • bioimaging
  • diagnostics
  • gold nanoparticles
  • nanomedicine


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