TY - JOUR
T1 - Engineered nanostructured materials for ofloxacin delivery
AU - Nuti, Silvia
AU - Fernández-Lodeiro, Javier
AU - Secco, Benedetta Del
AU - Rampazzo, Enrico
AU - Rodríguez-González, Benito
AU - Capelo, José L.
AU - Silva, Vanessa
AU - Igrejas, Gilberto
AU - Poeta, Patrícia
AU - Torres, Cármen
AU - Zaccheroni, Nelsi
AU - Prodi, Luca
AU - Oliveira, Elisabete
AU - Lodeiro, Carlos
N1 - CL, JC, JF-L, and EO thank the financial support by the Associate Laboratory Research Unit for Green Chemistry-Clean Processes and Technologies-LAQV which is financed by national funds from FCT/MEC (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265), as well as the PROTEOMASS Scientific Society (Portugal) for funding support (General Funding Grant). EO and JF-L thank FCT/MEC (Portugal) for their post-doctoral grants, SFRH/BPD/108660/2015 and SFRH/BPD/93982/2013, respectively. SN thanks the ERASMUS grant included in the agreement between the University of Bologna (Italy) and the Faculty of Science and Technology, University NOVA of Lisbon (Portugal), and to the PROTEOMASS Scientific Society for the travel grant support.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Antibiotic resistance is emerging as a growing worldwide problem and finding solutions to this issue is becoming a new challenge for scientists. As the development of new drugs slowed down, advances in nanotechnology offer great opportunities, with the possibility of designing new systems for carrying, delivery and administration of drugs already in use. Engineered combinations of the synthetic, broad-spectrum antibiotic ofloxacin, rarely studied in this field, with different types of silver, mesoporous silica-based and Pluronic/silica-based nanoparticles have been explored. The nanocarriers as silver core@silica mesoporous (AgMSNPs) and dye-doped silica nanoparticles functionalized with ofloxacin were synthesized and their antibacterial properties studied against S. aureus and E. coli. The best antibacterial results were obtained for the AgMSNPs nanosystem@ofloxacin for the strain S. aureus ATCC 25923, with MIC and MBC values of 5 and 25 μg/mL, proving the efficacy and synergetic effect of the antibiotic and the Ag core of the nanoparticles.
AB - Antibiotic resistance is emerging as a growing worldwide problem and finding solutions to this issue is becoming a new challenge for scientists. As the development of new drugs slowed down, advances in nanotechnology offer great opportunities, with the possibility of designing new systems for carrying, delivery and administration of drugs already in use. Engineered combinations of the synthetic, broad-spectrum antibiotic ofloxacin, rarely studied in this field, with different types of silver, mesoporous silica-based and Pluronic/silica-based nanoparticles have been explored. The nanocarriers as silver core@silica mesoporous (AgMSNPs) and dye-doped silica nanoparticles functionalized with ofloxacin were synthesized and their antibacterial properties studied against S. aureus and E. coli. The best antibacterial results were obtained for the AgMSNPs nanosystem@ofloxacin for the strain S. aureus ATCC 25923, with MIC and MBC values of 5 and 25 μg/mL, proving the efficacy and synergetic effect of the antibiotic and the Ag core of the nanoparticles.
KW - Antibiotics
KW - Bacteria
KW - Mesoporous silica nanoparticles
KW - Ofloxacin
KW - Silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85059937593&partnerID=8YFLogxK
U2 - 10.3389/fchem.2018.00554
DO - 10.3389/fchem.2018.00554
M3 - Article
C2 - 30538980
AN - SCOPUS:85059937593
SN - 2296-2646
VL - 6
JO - Frontiers in Chemistry
JF - Frontiers in Chemistry
IS - NOV
M1 - 554
ER -