Abstract
An organocatalytic domino reaction consisting of Michael addition/intramolecular alkylation between ,-unsaturated aldehydes and bromophosphonoacetates was developed. Highly functionalised cyclopropylphosphonates containing three chiral centres, one of them quaternary, were obtained with good diastereoselectivities of up to 83:17 and very high enantioselectivities of up to 99%.
Original language | English |
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Pages (from-to) | 152-163 |
Journal | European Journal of Organic Chemistry |
Volume | 2014 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Keywords
- Aldehydes
- Cyclopropanes
- Domino reactions
- Michael addition
- Organocatalysis