Enantioselective addition of alkynes to imines in ionic liquids

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43 Citations (Scopus)


The enantioselective alkyne-imine addition catalysed by copper(I)-bis(oxazoline) (box) can be efficiently performed in the ionic liquid 1-n-butyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf 2]. Several substrates were tested and the reuse of the catalytic CuOTf/(box) was carried out for six cycles allowing high overall yield (87%) and enantioselectivity (first cycle 94%, sixth cycle 89%).

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal Of Molecular Catalysis A-Chemical
Issue number1
Publication statusPublished - 18 May 2004


  • Enantioselective catalysis
  • Imines
  • Ionic liquids
  • Propargylamines
  • Recycling
  • Reuse


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