TY - JOUR
T1 - En face Ultrawidefield OCT of the Vortex Vein System in Central Serous Chorioretinopathy
AU - Ramtohul, Prithvi
AU - Cabral, Diogo
AU - Oh, Daniel
AU - Galhoz, Daniel
AU - Freund, K. Bailey
N1 - Funding Information:
P.R. is supported by The Philippe Foundation . D.C was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140), The Macula Foundation , Inc, New York, New York (P.R.).
Funding Information:
The author(s) have made the following disclosure(s): K.B.F.: Consultant – Genentech, Zeiss, Heidelberg Engineering, Allergan Inc, Bayer, Novartis; Funding – Genentech, Roche.P.R. is supported by The Philippe Foundation. D.C was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140), The Macula Foundation, Inc, New York, New York (P.R.).
Publisher Copyright:
© 2022 American Academy of Ophthalmology
PY - 2023/4
Y1 - 2023/4
N2 - Purpose: To investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate salient features of the choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Design: Retrospective observational case series. Participants: Patients diagnosed with CSC who underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging were included. Methods: Widefield OCT imaging was performed with a horizontal 23- × vertical 20-mm field of view of 5 visual fixations (1 central and 4 peripheral fixations) to compose structural en face UWF OCT montage images and UWF choroidal thickness maps. Automated image alignment was performed before grading. Main Outcome Measures: A comparison of choroidal vascular findings seen with UWF ICGA and en face UWF OCT images, including size and distribution of choroidal venous drainage areas and identification of dilated choroidal veins (pachyvessels) crossing the physiologic choroidal watershed zones. The spatial correlation between choroidal vascular hyperpermeability on UWF ICGA images and areas of choroidal thickening on UWF choroidal thickness maps was determined. Results: Forty-two eyes from 27 patients with CSC with a mean age of 56 ± 12 years (range, 31–77 years) were included. Quantitative measures of vortex vein drainage areas on en face UWF OCT images were significantly and positively correlated with those obtained with UWF ICGA (mean Pearson r = 0.825, P < 0.01). Identification of pachyvessels crossing the choroidal watershed zones showed an excellent correlation between UWF ICGA and en face UWF OCT images (mean Spearman ρ = 0.873, P < 0.01). In all cases, choroidal vascular hyperpermeability was observed on UWF ICGA spatially colocalized with areas of choroidal thickening on the UWF choroidal thickness map. Congestion within the entire drainage area of the dominant vortex systems was observed on UWF choroidal thickness maps. Conclusions: In eyes with CSC, noninvasive en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA. Ultrawidefield OCT choroidal thickness maps enable quantitative assessment of choroidal congestion.
AB - Purpose: To investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate salient features of the choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Design: Retrospective observational case series. Participants: Patients diagnosed with CSC who underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging were included. Methods: Widefield OCT imaging was performed with a horizontal 23- × vertical 20-mm field of view of 5 visual fixations (1 central and 4 peripheral fixations) to compose structural en face UWF OCT montage images and UWF choroidal thickness maps. Automated image alignment was performed before grading. Main Outcome Measures: A comparison of choroidal vascular findings seen with UWF ICGA and en face UWF OCT images, including size and distribution of choroidal venous drainage areas and identification of dilated choroidal veins (pachyvessels) crossing the physiologic choroidal watershed zones. The spatial correlation between choroidal vascular hyperpermeability on UWF ICGA images and areas of choroidal thickening on UWF choroidal thickness maps was determined. Results: Forty-two eyes from 27 patients with CSC with a mean age of 56 ± 12 years (range, 31–77 years) were included. Quantitative measures of vortex vein drainage areas on en face UWF OCT images were significantly and positively correlated with those obtained with UWF ICGA (mean Pearson r = 0.825, P < 0.01). Identification of pachyvessels crossing the choroidal watershed zones showed an excellent correlation between UWF ICGA and en face UWF OCT images (mean Spearman ρ = 0.873, P < 0.01). In all cases, choroidal vascular hyperpermeability was observed on UWF ICGA spatially colocalized with areas of choroidal thickening on the UWF choroidal thickness map. Congestion within the entire drainage area of the dominant vortex systems was observed on UWF choroidal thickness maps. Conclusions: In eyes with CSC, noninvasive en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA. Ultrawidefield OCT choroidal thickness maps enable quantitative assessment of choroidal congestion.
KW - Central serous chorioretinopathy
KW - Choroidal venous insufficiency
KW - En face OCT
KW - Indocyanine green angiography
KW - OCT
KW - Ultrawidefield imaging
KW - Vortex vein
UR - http://www.scopus.com/inward/record.url?scp=85142211485&partnerID=8YFLogxK
U2 - 10.1016/j.oret.2022.10.001
DO - 10.1016/j.oret.2022.10.001
M3 - Article
C2 - 36228952
AN - SCOPUS:85142211485
SN - 2468-6530
VL - 7
SP - 346
EP - 353
JO - Ophthalmology Retina
JF - Ophthalmology Retina
IS - 4
ER -