Emerging therapeutic targets in multiple sclerosis

Paulo Fontoura, Lawrence Steinman, Ariel Miller

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Purpose of review The aim of this review is to describe the recent findings regarding the pathogenesis of multiple sclerosis and their translation to new therapies. Recent findings Basic research is providing new insights into the immune elements involved in the pathogenesis of multiple sclerosis both in the periphery as well as in the central nervous system. Unveiling the complex interplay of the molecules-involved in the immunological cascade of the disease supplies new targets for the development of new immunotherapeutic strategies. Similarly, clinical studies and identification of distinct sub groups of patients based on their responsiveness to immunotherapies provides support for the existence,of immunopathological disease subtypes that seem to require different therapeutic approaches. These studies extend the theoretical basis that facilitates development of neuroprotective and repair-promoting therapeutic strategies. Summary The application of novel and cutting-edge technologies in the fields of genomics and proteomics is providing a better understanding of the genetic and environmental factors involved in multiple sclerosis susceptibility and as well as the detection of biomarkers for disease activity and response to therapy. Implementation of these facilitates identification of new targets for therapy towards tailoring treatment to the individual patient with multiple sclerosis..
Original languageEnglish
Pages (from-to)260-266
Number of pages7
JournalCurrent Opinion In Neurology
Volume19
Issue number3
DOIs
Publication statusPublished - Jun 2006

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