Emerging role of Sirtuin 2 in the regulation of mammalian metabolism

P Gomes; Tiago F Outeiro; C Cavadas

doi:10.1016/j.tips.2015.08.001

Emerging role of Sirtuin 2 in the regulation of mammalian metabolism

P Gomes, Tiago F Outeiro, C Cavadas

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

Sirtuins are an evolutionarily conserved family of NAD(+)-dependent deacylases that display diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7). The purpose of this review is to summarize the most recent findings about the potential roles and effects of SIRT2 in mammalian metabolic homeostasis. We discuss the different functions and targets of SIRT2 in various physiological processes, including adipogenesis, fatty acid oxidation, gluconeogenesis, and insulin sensitivity. We also cover the role of SIRT2 in inflammation and oxidative stress due to the possible implications for metabolic disorders. Finally, we consider its potential as a therapeutic target for the prevention and treatment of type 2 diabetes.

Original language	English
Pages (from-to)	756-768
Journal	Trends In Pharmacological Sciences
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/j.tips.2015.08.001
Publication status	Published - Nov 2015

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title = "Emerging role of Sirtuin 2 in the regulation of mammalian metabolism",

abstract = "Sirtuins are an evolutionarily conserved family of NAD(+)-dependent deacylases that display diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7). The purpose of this review is to summarize the most recent findings about the potential roles and effects of SIRT2 in mammalian metabolic homeostasis. We discuss the different functions and targets of SIRT2 in various physiological processes, including adipogenesis, fatty acid oxidation, gluconeogenesis, and insulin sensitivity. We also cover the role of SIRT2 in inflammation and oxidative stress due to the possible implications for metabolic disorders. Finally, we consider its potential as a therapeutic target for the prevention and treatment of type 2 diabetes.",

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author = "P Gomes and Outeiro, {Tiago F} and C Cavadas",

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AU - Outeiro, Tiago F

AU - Cavadas, C

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PY - 2015/11

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AB - Sirtuins are an evolutionarily conserved family of NAD(+)-dependent deacylases that display diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7). The purpose of this review is to summarize the most recent findings about the potential roles and effects of SIRT2 in mammalian metabolic homeostasis. We discuss the different functions and targets of SIRT2 in various physiological processes, including adipogenesis, fatty acid oxidation, gluconeogenesis, and insulin sensitivity. We also cover the role of SIRT2 in inflammation and oxidative stress due to the possible implications for metabolic disorders. Finally, we consider its potential as a therapeutic target for the prevention and treatment of type 2 diabetes.

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KW - SACCHAROMYCES-CEREVISIAE

KW - ADIPOCYTE DIFFERENTIATION

KW - TUBULIN DEACETYLASE

KW - ATP-CITRATE LYASE

KW - FATTY-ACID OXIDATION

KW - DEACETYLASE ACTIVITY

KW - CALORIE RESTRICTION

KW - DIET-INDUCED OBESITY

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ER -

Emerging role of Sirtuin 2 in the regulation of mammalian metabolism

Abstract

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