@article{7f53264ba36d49b59bd1438c5952868c,
title = "Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era",
abstract = "Serotype 1 pneumococci are rarely isolated from carriers, but are an important cause of pneumococcal invasive disease in many regions of the world. This report describes the emergence and expansion of a single serotype 1 lineage (characterised by multilocus sequence type 306) among healthy carriers attending day-care centres in Portugal. The prevalence of serotype1 strains among all pneumococci increased from 0% in 2001 and 2002, to 0.4% in 2003, and 3.1% in 2006. These observations paralleled the introduction and increased use of the seven-valent pneumococcal conjugate vaccine in the study group, suggesting a direct relationship between these events.",
keywords = "Carriage, Colonisation, Conjugate vaccine, Pneumococci, Serotype 1, Vaccine",
author = "S{\'o}nia Nunes and Raquel S{\'a}-Le{\~a}o and Pereira, {Liliana C.} and {de Lencastre}, Herminia",
note = "Funding Information: SN and RS-L contributed equally to this work. SN was supported by grants from EURIS (011/BIC/01) and PREVIS (010/BIC/04), and RS-L was supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia (SFRH/BPD/14596/2003 and SFRH/BPD/30871/2006). This work was also supported by projects EURIS (contract QKL2-CT-2000-01020) and PREVIS (contract LSHM-CT-2003-503413) from the European Commission. We thank R. Mato, I. Santos Sanches, A. Brito-Av{\^o}, J. Saldanha, N. Fraz{\~a}o, N. Sousa, C. Simas, I. Cris{\'o}stomo, A. Sim{\~o}es and A. Gon{\c c}alves for participating in studies that led to the isolation of the strains described in the study. This publication made use of the Multilocus Sequence Typing website ( http://www.mlst.net ) at Imperial College London, funded by the Wellcome Trust. The authors have no conflicts of interest to declare.",
year = "2008",
month = jan,
doi = "10.1111/j.1469-0691.2007.01871.x",
language = "English",
volume = "14",
pages = "82--84",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "European Society of Clinical Microbiology and Infectious Diseases | Elsevier",
number = "1",
}