Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era

Sónia Nunes, Raquel Sá-Leão, Liliana C. Pereira, Herminia de Lencastre

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28 Citations (Scopus)

Abstract

Serotype 1 pneumococci are rarely isolated from carriers, but are an important cause of pneumococcal invasive disease in many regions of the world. This report describes the emergence and expansion of a single serotype 1 lineage (characterised by multilocus sequence type 306) among healthy carriers attending day-care centres in Portugal. The prevalence of serotype1 strains among all pneumococci increased from 0% in 2001 and 2002, to 0.4% in 2003, and 3.1% in 2006. These observations paralleled the introduction and increased use of the seven-valent pneumococcal conjugate vaccine in the study group, suggesting a direct relationship between these events.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalClinical Microbiology and Infection
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Carriage
  • Colonisation
  • Conjugate vaccine
  • Pneumococci
  • Serotype 1
  • Vaccine

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