TY - JOUR
T1 - Electrospun composite cellulose acetate/iron oxide nanoparticles non-woven membranes for magnetic hyperthermia applications
AU - Matos, Ricardo J. R.
AU - Chaparro, Catarina I. P.
AU - Silva, Jorge C.
AU - Valente, Manuel Almeida
AU - Borges, João Paulo
AU - Soares, Paula I. P.
N1 - Sem PDF conforme despacho.
info:eu-repo/grantAgreement/FCT/5876/147333/PT#
This work is funded by National Funds through FCT - Portuguese Foundation for Science and Technology , Reference UID/CTM/50025/2013 and FEDER funds through the COMPETE 2020 Program under the project number POCI-01-0145-FEDER-007688.
PY - 2018/10/15
Y1 - 2018/10/15
N2 - In the present work composite membranes were produced by combining magnetic nanoparticles (NPs) with cellulose acetate (CA) membranes for magnetic hyperthermia applications. The non-woven CA membranes were produced by electrospinning technique, and magnetic NPs were incorporated by adsorption at fibers surface or by addition to the electrospinning solution. Therefore, different designs of composite membranes were obtained. Superparamagnetic NPs synthesized by chemical precipitation were stabilized either with oleic acid (OA) or dimercaptosuccinic acid (DMSA) to obtain stable suspensions at physiological pH. The incorporation of magnetic NP into CA matrix was confirmed by scanning and transmission electron microscopy. The results showed that adsorption of magnetic NPs at fibers’ surface originates composite membranes with higher heating ability than those produced by incorporation of magnetic NPs inside the fibers. However, adsorption of magnetic NPs at fibers’ surface can cause cytotoxicity depending on the NPs concentration. Tensile tests demonstrated a reinforcement effect caused by the incorporation of magnetic NPs in the non-woven membrane.
AB - In the present work composite membranes were produced by combining magnetic nanoparticles (NPs) with cellulose acetate (CA) membranes for magnetic hyperthermia applications. The non-woven CA membranes were produced by electrospinning technique, and magnetic NPs were incorporated by adsorption at fibers surface or by addition to the electrospinning solution. Therefore, different designs of composite membranes were obtained. Superparamagnetic NPs synthesized by chemical precipitation were stabilized either with oleic acid (OA) or dimercaptosuccinic acid (DMSA) to obtain stable suspensions at physiological pH. The incorporation of magnetic NP into CA matrix was confirmed by scanning and transmission electron microscopy. The results showed that adsorption of magnetic NPs at fibers’ surface originates composite membranes with higher heating ability than those produced by incorporation of magnetic NPs inside the fibers. However, adsorption of magnetic NPs at fibers’ surface can cause cytotoxicity depending on the NPs concentration. Tensile tests demonstrated a reinforcement effect caused by the incorporation of magnetic NPs in the non-woven membrane.
KW - Cellulose acetate
KW - Composite membranes
KW - Electrospinning
KW - Fibers
KW - Iron oxide nanoparticles
KW - Magnetic hyperthermia
UR - http://www.scopus.com/inward/record.url?scp=85048593980&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2018.06.048
DO - 10.1016/j.carbpol.2018.06.048
M3 - Article
C2 - 30093046
AN - SCOPUS:85048593980
SN - 0144-8617
VL - 198
SP - 9
EP - 16
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -