Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications

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Abstract

Electronic controlled drug release from fibres was studied using ibuprofen as a model drug, one of the most popular analgesics, to impregnate gauze and cellulose acetate (CA) membranes. Conductivity in the range of 1-10 mS cm−1was obtained in polypyrrole (Ppy) functionalised gauze and CA fibres, providing voltage-controlled drug release in a system consisting of Ppy/Ibuprofen/Ppy membranes and an Ag electrode. SEM images evidenced the Ppy adhesion to fibres and Micro Raman spectra proved drug incorporation and release. A small wound adhesive built with these membranes retains ibuprofen at 1.5 V and quickly releases it when −0.5 V is applied.

Original languageEnglish
Pages (from-to)3515-3522
Number of pages8
JournalJournal of Materials Chemistry B
Volume9
Issue number16
DOIs
Publication statusPublished - 28 Apr 2021

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