Electron transfer between multihaem cytochromes c3 from Desulfovibrio africanus

Pedro O. Quintas, Márcia S. Oliveira, Teresa Catarino, David L. Turner

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The tetrahaem type I cytochromes c3 from Desulfovibrionaceae shuttle electrons from a periplasmic hydrogenase to transmembrane electron transfer complexes. In D. africanus, it is believed that the electrons are received by another tetrahaem cytochrome c3, denoted type II, which is associated with the membrane complex. Thermodynamic measurements show that the type I cytochrome c3 has the potential to transfer two electrons at a time. This study uses two-dimensional NMR to investigate the exchange of electrons between type I and type II cytochromes c3 at equilibrium in intermediate stages of oxidation. The results indicate that the two proteins are physiological partners but that only single-electron transfers occur in solution.

Original languageEnglish
Pages (from-to)502-506
Number of pages5
JournalBiochimica et Biophysica Acta-Bioenergetics
Issue number4
Publication statusPublished - Apr 2013


  • 2D NMR exchange spectroscopy
  • Diffusion control
  • Electron transfer
  • Keywords
  • Marcus theory
  • Multiheme cytochrome
  • Sulphate-reducing bacterium


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