Electro-membrane separations in biotechnology

Zdravka Lazarova, Venko Beschkov, Svetlozar Velizarov

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1 Citation (Scopus)


Membrane processes are of crucial importance for downstream processing in biotechnology. This is due to their selectivity and the mild operating conditions, enabling to extract target products without damages caused by overheating and chemical agents. Besides the most spread membrane processes like ultrafiltration and reverse osmosis, electrodialysis is very important for removal and extraction of electrically charged products, i. e. anions of organic acids, some antibiotics, etc. The electrodialysis process can be organized in batch or continuous mode. On the other hand, in the electro-crossflow filtration, the transport of target solutes across the membrane is guided by two main driving forces, the transmembrane pressure and the electric potential. This combination enables various possibilities for more selective and efficient downstream processing in biotechnology. This chapter provides a brief overview of recent achievements of electrodialysis in selected bioproductsseparations and recovery. A special focus, including original experimental data, is then given to electro-filtration, which is a powerful tool creating new opportunities for performing separations on the basis of both electric charge and particle size differences.

Original languageEnglish
Article number20180063
JournalPhysical Sciences Reviews
Issue number8
Publication statusPublished - 1 Aug 2020


  • aminoacids
  • bioactive albumin
  • donnan dialysis
  • downstream processing
  • electric field
  • electro-filtration
  • electrodialysis
  • lactic acid
  • microfiltration
  • organic acids
  • rabbit albumin
  • ultrafiltration


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