Efficient α-chlorination of carbonyl containing compounds under basic conditions using methyl chlorosulfate

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

An efficient method for the α-chlorination of ketones under basic conditions is described using methyl chlorosulfate. Its applicability for the chlorination of other functional groups has also been studied and it is equally useful for the synthesis of α-chloroesters and amides. Methyl chlorosulfate is described for the first time as a positive chlorine source. Some aldol reactions which occur during the chlorination of some substrates are also reported.

Original languageEnglish
Pages (from-to)1233-1238
Number of pages6
JournalTetrahedron Letters
Volume59
Issue number13
DOIs
Publication statusPublished - 28 Mar 2018

Keywords

  • Chlorination
  • Chloroamide
  • Chloroester
  • Chloroketone
  • Halogenation
  • Methyl chlorosulfate

Fingerprint

Dive into the research topics of 'Efficient α-chlorination of carbonyl containing compounds under basic conditions using methyl chlorosulfate'. Together they form a unique fingerprint.

Cite this